Telomere length is a crucial factor for both normal chromosomal function and senescence.
Mean telomere length in humans shows considerable interindividual variation and strong …

Telomeres play a central role in cellular senescence and cancer pathobiology and are
associated with age-related diseases such as atherosclerosis and dementia. Telomere …

Telomere-specific clones are a valuable resource for the characterization of chromosomal
rearrangements. We previously reported a first-generation set of human telomere probes …

Interindividual variation in mean leukocyte telomere length (LTL) is associated with cancer
and several age-associated diseases. We report here a genome-wide meta-analysis of …

In this study the telomere length distribution on individual chromosome arms in humans has
been characterized. Using fluorescent in situ hybridisation (FISH) followed by computer …

In human cancer cells with telomeres that have been over-lengthened by exogenous
telomerase activity, telomere shortening can occur by a process that generates circles of …

Cellular telomere length is linked to replicative life span. Telomere repeats are lost in
peripheral blood cells in vivo by age, and women show less telomere attrition than men …

Little is known about the mechanisms that regulate species-specific telomere length,
particularly in mammalian species. The genetic regulation of telomere length was therefore …

A complete set of telomere region–specific FISH probes designed to hybridize to the unique
subtelomeric regions of every human chromosome was initially described in 1996 (National …

Remarkable progress has been made during the last 2 decades in understanding telomere
biology at the molecular and cellular levels. Clinical epidemiology research of human …