Development of the human placenta

MY Turco, A Moffett - Development, 2019 - journals.biologists.com
The placenta is essential for normal in utero development in mammals. In humans, defective
placental formation underpins common pregnancy disorders such as pre-eclampsia and …

Human placenta and trophoblast development: key molecular mechanisms and model systems

M Knöfler, S Haider, L Saleh, J Pollheimer… - Cellular and Molecular …, 2019 - Springer
Abnormal placentation is considered as an underlying cause of various pregnancy
complications such as miscarriage, preeclampsia and intrauterine growth restriction, the …

[HTML][HTML] Human placental development and function

T Cindrova-Davies, AN Sferruzzi-Perri - Seminars in cell & developmental …, 2022 - Elsevier
The placenta is a transient fetal organ that plays a critical role in the health and wellbeing of
both the fetus and its mother. Functionally, the placenta sustains the growth of the fetus as it …

Mechanisms of early placental development in mouse and humans

M Hemberger, CW Hanna, W Dean - Nature Reviews Genetics, 2020 - nature.com
The importance of the placenta in supporting mammalian development has long been
recognized, but our knowledge of the molecular, genetic and epigenetic requirements that …

How to make a placenta: mechanisms of trophoblast cell differentiation in mice–a review

JC Cross - Placenta, 2005 - Elsevier
The word placenta is derived from the Latin term meaning 'flat cake'. Despite the rather
humble name, the placenta is an amazing organ that forms both the interface for selective …

A placenta for life

R John, M Hemberger - Reproductive biomedicine online, 2012 - Elsevier
The chorioallantoic placenta is the defining organ of eutherians that has enabled prolonged
intrauterine gestation. As such, normal placental development and function are essential for …

Modelling human placental villous development: designing cultures that reflect anatomy

JL James, A Lissaman, YNS Nursalim… - Cellular and Molecular …, 2022 - Springer
The use of in vitro tools to study trophoblast differentiation and function is essential to
improve understanding of normal and abnormal placental development. The relative …

[PDF][PDF] Genes, development and evolution of the placenta

JC Cross, D Baczyk, N Dobric, M Hemberger… - Placenta, 2003 - researchgate.net
Comparing the placenta from one species to another can be a challenging task. On one
hand, the gross anatomy of the placenta is at least superficially rather different among …

A differentiation roadmap of murine placentation at single-cell resolution

X Jiang, Y Wang, Z Xiao, L Yan, S Guo, Y Wang, H Wu… - Cell Discovery, 2023 - nature.com
The placenta is one of the most important yet least understood organs. Due to the limitations
of conventional research approaches, we are still far from a comprehensive understanding …

Placental formation in early pregnancy: how is the centre of the placenta made?

AL Boss, LW Chamley, JL James - Human reproduction update, 2018 - academic.oup.com
BACKGROUND Correct development of the placenta is critical to establishing pregnancy
and inadequate placentation leads to implantation failure and miscarriage, as well as later …