An epigenetic clock analysis of race/ethnicity, sex, and coronary heart disease
Background Epigenetic biomarkers of aging (the “epigenetic clock”) have the potential to
address puzzling findings surrounding mortality rates and incidence of cardio-metabolic …
address puzzling findings surrounding mortality rates and incidence of cardio-metabolic …
The socioeconomic gradient in epigenetic ageing clocks: evidence from the multi-ethnic study of atherosclerosis and the health and retirement study
Epigenetic clocks have been widely used to predict disease risk in multiple tissues or cells.
Their success as a measure of biological ageing has prompted research on the connection …
Their success as a measure of biological ageing has prompted research on the connection …
Prospective study of epigenetic age acceleration and incidence of cardiovascular disease outcomes in the ARIC study (Atherosclerosis Risk in Communities)
NS Roetker, JS Pankow, J Bressler… - Circulation: Genomic …, 2018 - Am Heart Assoc
Background: DNA methylation-based patterns of biological aging, known as epigenetic age
acceleration, are predictive of all-cause mortality, but little is known about their association …
acceleration, are predictive of all-cause mortality, but little is known about their association …
Cardiovascular health and four epigenetic clocks
YH Lo, WY Lin - Clinical Epigenetics, 2022 - Springer
Background Cardiovascular health (CVH) was defined by the American Heart Association
as an integrative idealness of seven clinical or lifestyle factors. Based on populations of …
as an integrative idealness of seven clinical or lifestyle factors. Based on populations of …
Genome-wide association studies identify 137 genetic loci for DNA methylation biomarkers of aging
DL McCartney, JL Min, RC Richmond, AT Lu… - Genome biology, 2021 - Springer
Background Biological aging estimators derived from DNA methylation data are heritable
and correlate with morbidity and mortality. Consequently, identification of genetic and …
and correlate with morbidity and mortality. Consequently, identification of genetic and …
Association of cardiovascular health and epigenetic age acceleration
Background Cardiovascular health (CVH) has been defined by the American Heart
Association (AHA) as the presence of the “Life's Simple 7” ideal lifestyle and clinical factors …
Association (AHA) as the presence of the “Life's Simple 7” ideal lifestyle and clinical factors …
Epigenetic age acceleration reflects long-term cardiovascular health
Rationale: Epigenetic aging is a novel measure of biological age, reflecting exposures and
disease risks independent of chronological age. It may serve as a useful biomarker of …
disease risks independent of chronological age. It may serve as a useful biomarker of …
Genetic evidence for causal effects of socioeconomic, lifestyle, and cardiometabolic factors on epigenetic-age acceleration
Abstract GrimAge acceleration (GrimAgeAccel) and PhenoAge acceleration
(PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging …
(PhenoAgeAccel) are DNA methylation-based markers of accelerated biological aging …
An epigenome-wide association study of sex-specific chronological ageing
Background Advanced age is associated with cognitive and physical decline and is a major
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …
risk factor for a multitude of disorders. There is also a gap in life expectancy between males …
[HTML][HTML] An epigenetic biomarker of aging for lifespan and healthspan
Identifying reliable biomarkers of aging is a major goal in geroscience. While the first
generation of epigenetic biomarkers of aging were developed using chronological age as a …
generation of epigenetic biomarkers of aging were developed using chronological age as a …