Melanins have been associated with the development of melanoma and its resistance to
photodynamic therapy (PDT). Singlet molecular oxygen (1O2), which is produced by …

Cutaneous malignant melanoma (CMM) is one of the most rapidly increasing cancers in the
western world (Bowden, 2004). Frequency of its occurrence is closely associated with skin …

Melanin synthesis is an oxygen‐dependent process that acts as a potential source of
reactive oxygen species (ROS) inside pigment‐forming cells. The synthesis of the lighter …

The human skin and eye melanin is commonly viewed as an efficient photoprotective agent.
To elucidate the molecular mechanism of the melanin-dependent photoprotection, we …

UV‐induced DNA damage can lead to melanoma, the most dangerous form of skin cancer.
Understanding the mechanisms employed by melanocytes to protect against UV is therefore …

Melanins, pigments of photoprotection and camouflage, are very photoreactive and can both
absorb and emit active oxygen species. Nevertheless, black skinned individuals rarely …

Skin cancer incidence is dramatically increasing worldwide, with exposure to ultraviolet
radiation (UVR) a predominant factor. The UVA component initiates oxidative stress in …

Visible light can induce the generation of singlet oxygen and can cause oxidative stress,
especially in melanocytes due to melanin photosensitization. Currently, there is no organic …

Eumelanin is a heterogeneous polymer composed of 5, 6-dihydroxyindole-2-carboxylic acid
(DHICA) and 5, 6-dihydroxyindole (DHI). Studies have shown that DHICA promotes single …

Melanins, the main epidermal pigments of man, have been viewed traditionally as
performing photoprotective and antioxidant functions, yet increasing evidence indicates they …