1 Ischemic heart disease stands as the foremost global cause of mortality. Myocardial
ischemia results in damage to cardiomyocytes which can further lead to impaired heart …

Cardiac tolerance to ischaemia can be increased by dietary interventions such as fasting,
which is associated with significant changes in myocardial gene expression. Among the …

Similar to DNA modifications, an epitranscriptome of mRNA modifications emerged over the
last decade. Specifically, the discovery of the N6-methyladenosine (m6A) as reversible …

Similar to DNA modifications, an epitranscriptome of mRNA modifications emerged over the
last few years in the cardiovascular system. Specifically, the discovery of the N6 …

Elderly patients are more susceptible to ischemic injury. N6-methyladenosine (m6A)
modification is the most abundant reversible epitranscriptomic modification in mammalian …

Introduction: Emerging evidence suggests that post-transcriptional modifications of mRNAs
are vital to their stability, nuclear export, cellular compartmentalization, translation to …

Background: Adenosine in RNA is a substrate for addition or removal of methyl group.
Reported five decades ago, methylated adenosine (m6A), the most abundant and …

RNA modifications are enzymatic RNA base modifications that increase the RNA alphabet
from the 4 canonical nucleotides to more than 140 (a brief overview of RNA modifications is …

Post-transcriptional RNA modification has been observed in all kingdoms of life and more
than a hundred different types of RNA modifications decorate the chemical and topological …

Hypoxia as a crucial pathogenesis factor usually results in huge harmful effects on cardiac
injury and dysfunction. Our previous study has uncovered the global transcriptome and …