Osteopetrosis is a metabolic bone disease characterized by a systemic increase in skeletal
mass. It results from a defect in the production or function of osteoclasts and is inherited in …

Osteopetrosis is a metabolic bone disease inherited in a number of species including
human beings and characterized by a generalized increase in skeletal density detected …

Abstract Felix R, Hofstetter W, Cecchini MG. Recent developments in the understanding of
the pathophysiology of osteopetrosis. Eur J Endocrinol 1996; 134: 143–56. ISSN 0804 …

The osteopetroses are a heterogeneous group of bone remodeling disorders characterized
by an increase in bone density due to a defect in osteoclastic bone resorption. In humans …

Osteopetrosis is a metabolic bone disease characterized by excessive accumulation of
skeletal mass due to a reduction in bone resorption. The pathogenesis of osteopetrosis is …

Throughout life, bone tissue is in a constant state of turnover. This process of bone
remodeling is the result of a combination of sequential removal of bone tissue by osteoclasts …

Osteopetrosis comprises a group of rare metabolic diseases of skeletal development that
are characterized by a generalized increase in skeletal mass resulting from reduced …

Progress has been made in recent years on the cell biology of the osteoclast and the
pathogenesis of congenital osteopetrosis. New information is critically evaluated and …

This review of the mechanism of osteopetrosis incriminates molecular defects in osteoclasts
as the cause of the imbalance between bone formation by osteoblasts and bone resorption …

Bone resorption is one of the main mechanisms of maintaining the homeostatic regulation of
calcium and phosphate concentration in body fluid. In the last few decades much research in …