Doxorubicin (DOX) is an anthracycline antibiotic that is widely used as a chemotherapeutic
agent. However, usefulness of this agent is limited due to its cardiotoxic effects. The aim of …

Aminothiol amifostine (AMI) protects against toxic effects of both ionizing radiation and
numerous anticancer drugs. The aim of this study was to investigate the potential protective …

Doxorubicin (DOX) is one of the secondary metabolites of Streptomyces peucetius var.
caesius. It is a common and effective chemotherapeutic agent used for the treatment of …

Doxorubicin (DOX) is used in the treatment of cancer. However, cardiotoxicity is its major
dose-limiting factor. Mechanism of DOX–cardiac toxicity is not completely elucidated. The …

The chemotherapeutic agent doxorubicin (DOX) is associated with a dose-dependent
cardiotoxicity that can eventuate into heart failure. This study aimed to characterize the onset …

Doxorubicin (DOX) is an effective anticancer agent, but adverse cardiotoxic effects limit its
use. Compounds reducing DOX cardiotoxicity could improve its therapeutic index. This study …

Anthracyclines find vital uses in the treatment of solid tumors and other kind of malignancies.
A typical side effect observed with few agents of this class is dose-dependent cardiotoxicity …

Aim: Doxorubicin (DOX) is an effective chemotherapeutic drug. However, its clinical
application may be hampered by dose-dependent cardiotoxicity. Alcohol metabolite and …

Background Doxorubicin (DOX) is an effective antitumor agent, but its clinical usage is
limited due to adverse cardiotoxic effects. Several compounds have been studied to reduce …

Background Doxorubicin (DOX)-related cardiotoxicity may expose cancer survivors to
increased risk of cardiovascular morbidity and mortality. Here, we characterized the time …