Azathioprine is commonly used as an immunosuppressive antimetabolite in the treatment of
acute lymphoblastic leukemia, autoimmune disorders (such as Crohn's disease and …

Azathioprine is used frequently to treat several inflammatory conditions. However, treatment
is limited by adverse events—in particular, myelotoxicity. Thiopurine‐S‐methyltransferase …

Introduction Thiopurine drugs are purine nucleoside analogues used for treatment of
different immune-related conditions. To date, different studies highlighted the importance of …

TPMT and NUDT15 variants explain less than 25% of azathioprine‐associated
myelotoxicity. There are 25 additional genes in the thiopurine pathway that could also …

Azathioprine (brand names Imuran, Azasan) is an immunosuppressant that belongs to the
drug class of thiopurines. It is used with other drugs to prevent kidney transplant rejection …

Thiopurine methyltransferase catalyzes the S-methylation of azathioprine (AZA), 6-mercapto-
purine (6-MP) and thioguanine, medications widely used to treat malignancies, rheumatic …

Aim: To conduct a pragmatic, randomized controlled trial to assess whether thiopurine
methyltransferase (TPMT) genotyping prior to azathioprine reduces adverse drug reactions …

There is a large body of evidence that shows that impaired function polymorphisms are
predictive of reduced or absent thiopurine-S-methyltransferase (TPMT) enzyme function in …

Objective To study the distribution of the thiopurine methyltransferase (TPMT) genotype
among azathioprine (Aza)-tolerant and-intolerant patients with various disorders, and to …

Conclusion: In this report, we first provide detailed clinical and laboratory characteristics of
AZA-induced leukopenia in a patient with SS with a mutant NUDT15 R139C genotype (TT …