CD4+ T cells orchestrate adaptive immune responses through their capacity to recruit and
provide help to multiple immune effectors, in addition to exerting direct effector functions …

Host defense against viruses and intracellular parasites depends on effector CD8+ T cells,
whose optimal clonal expansion, differentiation, and memory properties require signals from …

Memory T cells are heterogeneous in expression of lymph node homing receptors,
delineating" central‐memory"(TCM, CD62Lhi/CCR7+) and" effector‐memory"(TEM …

Immunity to many intracellular pathogens requires the proliferation, differentiation, and
function of CD 8+ cytotoxic T lymphocytes (CTL s). While the majority of effector CTL s die …

CD8 T cell memory is characterized by rapid recall of effector function, increased
proliferation, and reduced activation requirements. Despite the extensive functional …

CD8+ T cells in different activation states have been difficult to identify phenotypically. In this
study we have investigated whether Mac-1 (CD11b) expression can be used as a criterion to …

Monocytes are effectors of the inflammatory response to microbes. Human CD14+
monocytes specialize in phagocytosis and production of reactive oxygen species and …

CD8+ T cell exhaustion impedes control of chronic viral infection; yet how new T cell
responses are mounted during chronic infection is unclear. Unlike T cells primed at the …

CD8 T cells play crucial roles in immune surveillance and defense against infections and
cancer. After encountering antigenic stimulation, naïve CD8 T cells differentiate and acquire …

CD4 T-cell–specific memory antiviral responses to human immunodeficiency virus type 1
(HIV-1) and cytomegalovirus (CMV) were investigated in 16 patients with documented …