Cytotoxic CD8+ T cells can effectively kill target cells by producing cytokines, chemokines,
and granzymes. Expression of these effector molecules is however highly divergent, and …

The mouse lymphoid organ-resident CD8α+ dendritic cell (DC) subset is specialized in Ag
presentation to CD8+ T cells. Recent evidence shows that mouse nonlymphoid tissue …

CD8 is critical for T cell recognition of peptide/class I major histocompatability complex
ligands, yet is down-regulated during activation of CD8 T cells. We report that loss of CD8 …

The identification and study of antigen-specific CD4 T cells, both in peripheral blood and in
tissues, is key for a broad range of immunological research, including vaccine responses …

The number of virus-specific CD8 T cells increases substantially during an acute infection.
Up to 90% of CD8 T cells are virus specific following lymphocytic choriomeningitis virus …

Abstract CD4+/CD8+ DP thymocytes are a well-described T cell developmental stage within
the thymus. However, once differentiated, the CD4+ lineage or the CD8+ lineage is …

In mouse, a subset of dendritic cells (DCs) known as CD8α+ DCs has emerged as an
important player in the regulation of T cell responses and a promising target in vaccination …

Cytotoxic T lymphocytes (CTL) respond to antigenic peptides presented on MHC class I
molecules. On most cells, these peptides are exclusively of endogenous, cytosolic origin …

Recent studies have demonstrated that in peripheral lymphoid tissues of normal mice and
healthy humans, 1% to 5% of αβ T-cell receptor–positive (TCR+) T cells are CD4 …

Dendritic cells (DC) have the unique capacities to induce primary T-cell responses. In mice,
CD8α+ DC are specialized to cross-prime CD8+ T cells and produce interleukin-12 (IL-12) …