p66shc, a member of the shc adaptor protein family, has been shown to participate in
regulation of mitochondrial homeostasis, apoptosis, and autophagosome formation. The …

Activation of CX3CR1 in microglia plays an important role in the development of neuropathic
pain. Here, we investigated whether neuropathic pain could be attenuated in spinal nerve …

Aim: To investigate whether p38 small-interfering RNA-loaded nanoparticles (p38 siRNA
NPs) attenuate spinal nerve ligation (SNL)-induced neuropathic pain in rats by suppressing …

Activation of nuclear factor-kappa B (NF-κB) in microglia plays a decisive role in the
progress of neuropathic pain, and the inhibitor of kappa B (IκB) is a protein that blocks the …

Aims: We investigated whether miRNA (miR) 146a-5p-loaded nanoparticles (NPs) can
attenuate neuropathic pain behaviors in the rat spinal nerve ligation-induced neuropathic …

Neuropathic pain (NP) is among the most intractable comorbidities of spinal cord injury.
Dysregulation of non-coding RNAs has also been implicated in the development of …

In vitro and in vivo models of Parkinson's disease were established to investigate the effects
of the lncRNA XIST/miR-199a-3p/Sp1/LRRK2 axis. The binding between XIST and miR …

Abstract Polo-like kinase 4 (PLK4) is one of the key regulators of centrosomal replication.
However, its role and mechanism in spinal cord injury (SCI) are still unclear. The SCI model …

Microglia play a critical role in neuropathic pain. Since upregulated Foxp3 in microglia
enhances tissue repair by resolving neuroinflammation in excitotoxin-induced neuronal …

Neuropathic pain is characterized by hyperalgesia, allodynia, and spontaneous pain.
Recent studies have shown that glycoprotein nonmetastatic melanoma B (GPNMB) plays a …