Reconstruction of the molecular pathways controlling organ development has been
hampered by a lack of methods to resolve embryonic progenitor cells. Here we describe a …

Cellular decision-making is mediated by a complex interplay of external stimuli with the
intracellular environment, in particular transcription factor regulatory networks. Here we have …

Cell identity is governed by the complex regulation of gene expression, represented as gene-
regulatory networks. Here we use gene-regulatory networks inferred from single-cell multi …

During gastrulation, cell types from all three germ layers are specified and the basic body
plan is established. However, molecular analysis of this key developmental stage has been …

Single-cell transcriptomic assays have enabled the de novo reconstruction of lineage
differentiation trajectories, along with the characterization of cellular heterogeneity and state …

Recent ChIP experiments of human and mouse embryonic stem cells have elucidated the
architecture of the transcriptional regulatory circuitry responsible for cell determination …

Background Reconstruction of executable mechanistic models from single-cell gene
expression data represents a powerful approach to understanding developmental and …

Single-cell technology enables study of signal transduction in a complex tissue at
unprecedented resolution. We describe CytoTalk for de novo construction of cell type …

Mammalian organogenesis is a remarkable process. Within a short timeframe, the cells of
the three germ layers transform into an embryo that includes most of the major internal and …

High‐throughput‐omics techniques have revolutionised biology, allowing for thorough and
unbiased characterisation of the molecular states of biological systems. However, cellular …