Innate immune response to SARS-CoV-2 infection: From cells to soluble mediators

D Ricci, MP Etna, F Rizzo, S Sandini, M Severa… - International journal of …, 2021 - mdpi.com
The vulnerability of humankind to SARS-CoV-2 in the absence of a pre-existing immunity,
the unpredictability of the infection outcome, and the high transmissibility, broad tissue …

Coinfection with SARS-CoV-2 and Influenza A Virus Increases Disease Severity and Impairs Neutralizing Antibody and CD4+ T Cell Responses

EH Kim, TQ Nguyen, MAB Casel, R Rollon… - Journal of …, 2022 - Am Soc Microbiol
Given the current coronavirus disease 2019 (COVID-19) pandemic, coinfection of severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2) and influenza A virus (IAV) is a …

[HTML][HTML] Heterogeneous SARS-CoV-2 kinetics due to variable timing and intensity of immune responses

K Owens, S Esmaeili, JT Schiffer - JCI insight, 2024 - ncbi.nlm.nih.gov
The viral kinetics of documented SARS-CoV-2 infections exhibit a high degree of
interindividual variability. We identified 6 distinct viral shedding patterns, which differed …

Dynamic innate immune response determines susceptibility to SARS-CoV-2 infection and early replication kinetics

NR Cheemarla, TA Watkins, VT Mihaylova… - Journal of Experimental …, 2021 - rupress.org
Initial replication of SARS-CoV-2 in the upper respiratory tract is required to establish
infection, and the replication level correlates with the likelihood of viral transmission. Here …

Insights from early mathematical models of 2019-nCoV acute respiratory disease (COVID-19) dynamics

JF Rabajante - arXiv preprint arXiv:2002.05296, 2020 - arxiv.org
In December 2019, a novel coronavirus (SARS-CoV-2) has been identified to cause acute
respiratory disease in humans. An outbreak of this disease has been reported in mainland …

The dichotomous and incomplete adaptive immunity in COVID-19 patients with different disease severity

L Gao, J Zhou, S Yang, L Wang, X Chen… - Signal transduction and …, 2021 - nature.com
The adaptive immunity that protects patients from coronavirus disease 2019 (COVID-19),
caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), is not well …

[HTML][HTML] Innate and adaptive immune responses against coronavirus

A Hosseini, V Hashemi, N Shomali, F Asghari… - Biomedicine & …, 2020 - Elsevier
Coronaviruses (CoVs) are a member of the Coronaviridae family with positive‐sense single-
stranded RNA. In recent years, the CoVs have become a global problem to public health …

Cellular immune response to COVID-19 and potential immune modulators

X Zhou, Q Ye - Frontiers in Immunology, 2021 - frontiersin.org
Coronavirus disease 2019 (COVID-19) is a respiratory infectious disease caused by severe
acute respiratory syndrome coronavirus 2 (SARS-CoV-2). Droplets and contacts serve as …

Diverse immunological factors influencing pathogenesis in patients with COVID-19: a review on viral dissemination, immunotherapeutic options to counter cytokine …

AA Rabaan, SH Al-Ahmed, MA Garout, AM Al-Qaaneh… - Pathogens, 2021 - mdpi.com
The pathogenesis of coronavirus disease 2019 (COVID-19), caused by severe acute
respiratory syndrome coronavirus 2 (SARS-CoV-2), is still not fully unraveled. Though …

Immune responses during COVID-19 infection

C Melenotte, A Silvin, AG Goubet, I Lahmar… - …, 2020 - Taylor & Francis
Over the past 16 years, three coronaviruses (CoVs), severe acute respiratory syndrome CoV
(SARS-CoV) in 2002, Middle East respiratory syndrome CoV (MERS-CoV) in 2012 and …