[HTML][HTML] Alternative splicing of lncRNAs in human diseases

J Chen, Y Liu, J Min, H Wang, F Li, C Xu… - American journal of …, 2021 - ncbi.nlm.nih.gov
Alternative splicing (AS), a vital post-transcription process for eukaryote gene expression
regulating, can efficiently improve gene utilization and increase the variety of RNA …

Long non-coding RNAs are involved in alternative splicing and promote cancer progression

J Ouyang, Y Zhong, Y Zhang, L Yang, P Wu… - British Journal of …, 2022 - nature.com
Alternative splicing (AS) is a key process in which precursor RNAs produce different mature
RNAs, and the disorder of AS is a key factor in promoting cancer development. Compared …

[HTML][HTML] The interplay between non-coding RNAs and alternative splicing: from regulatory mechanism to therapeutic implications in cancer

M Liu, S Zhang, H Zhou, X Hu, J Li, B Fu, M Wei… - Theranostics, 2023 - ncbi.nlm.nih.gov
Alternative splicing (AS) is a common and conserved process in eukaryotic gene regulation.
It occurs in approximately 95% of multi-exon genes, greatly enriching the complexity and …

Noncoding RNAs regulate alternative splicing in Cancer

Y Liu, X Liu, C Lin, X Jia, H Zhu, J Song… - Journal of Experimental & …, 2021 - Springer
AS (alternative splicing) is a fundamental process by which a gene can generate multiple
distinct mRNA transcripts to increase protein diversity. Defects in AS influence the …

Distinct regulatory functions and biological roles of lncRNA splice variants

MR Khan, M Avino, RJ Wellinger, B Laurent - Molecular Therapy-Nucleic …, 2023 - cell.com
Alternative splicing (AS) of RNA molecules is a key contributor to transcriptome diversity. In
humans, 90%–95% of multi-exon genes produce alternatively spliced RNA transcripts …

[HTML][HTML] Epigenetic regulation of alternative splicing

LY Zhu, YR Zhu, DJ Dai, X Wang… - American journal of …, 2018 - ncbi.nlm.nih.gov
Alternative splicing (AS) serves as an additional regulatory process for gene expression
after transcription, and it generates distinct mRNA species, and even noncoding RNAs …

The nexus of long noncoding RNAs, splicing factors, alternative splicing and their modulations

P Malakar, S Shukla, M Mondal, RK Kar, JA Siddiqui - RNA biology, 2024 - Taylor & Francis
The process of alternative splicing (AS) is widely deregulated in a variety of cancers.
Splicing is dependent upon splicing factors. Recently, several long noncoding RNAs …

Exploring the alternative splicing of long noncoding RNAs

MR Khan, RJ Wellinger, B Laurent - Trends in Genetics, 2021 - cell.com
Like protein-coding genes, long noncoding RNA (lncRNA) genes are composed of introns
and exons. After their transcription, lncRNAs are subject to constitutive and/or alternative …

LncAS2Cancer: a comprehensive database for alternative splicing of lncRNAs across human cancers

Y Deng, H Luo, Z Yang, L Liu - Briefings in Bioinformatics, 2021 - academic.oup.com
Accumulating studies demonstrated that the roles of lncRNAs for tumorigenesis were
isoform-dependent and their aberrant splicing patterns in cancers contributed to function …

Alternative RNA splicing and cancer

S Liu, C Cheng - Wiley Interdisciplinary Reviews: RNA, 2013 - Wiley Online Library
Alternative splicing of pre‐messenger RNA (mRNA) is a fundamental mechanism by which a
gene can give rise to multiple distinct mRNA transcripts, yielding protein isoforms with …