The development of technologies to promote vascularization of engineered tissue would
drive major developments in tissue engineering and regenerative medicine. Recently, we …

Objectives The bone tissue engineering primarily focuses on three‐dimensional co‐culture
systems, which physical and biological properties resemble the cell matrix of actual tissues …

Addressing the problem of vascularization is of vital importance when engineering three-
dimensional (3D) tissues. Endothelial cells are increasingly used in tissue-engineered …

Engraftment of tissue-engineered bone plays a pivotal role in the treatment of large bone
defects. However, promoting thorough vascularization in the central area of tissue …

The neovascularization of three‐dimensional voluminous tissues, such as bone, represents
an important challenge in tissue engineering applications. The formation of a preformed …

Most bone tissue–engineering research uses porous three-dimensional (3D) scaffolds for
cell seeding. In this work, scaffold-less 3D bone-like tissues were engineered from rat bone …

A key challenge in the treatment of large bone defects is the need to provide an adequate
and stable vascular supply as new tissue develops. Bone tissue engineering applies …

Over-dependence on existing synthetic scaffolds and insufficient vascularization limit the
development of tissue engineered bone (TEB). The purpose of this study is to fabricate …

Currently, most in vitro engineered bone tissues do not contain viable blood vessel systems,
so the vascularization depends on post-implantation angiogenesis from the host, which is …

Much research has been conducted on fabricating biomimetic biomaterials in vitro. Tissue
engineering approaches are often conducted by combining cells, scaffolds, and growth …