New pathophysiological insights and modern treatment of IBD

MA Engel, MF Neurath - Journal of gastroenterology, 2010 - Springer
Inflammatory bowel disease (IBD), which comprises two main types, namely, Crohn's
disease and ulcerative colitis, affects approximately 3.6 million people in the USA and …

[HTML][HTML] Pathogenesis of inflammatory bowel disease and recent advances in biologic therapies

DH Kim, JH Cheon - Immune network, 2017 - synapse.koreamed.org
Inflammatory bowel disease (IBD) is a chronic intestinal inflammatory disorder with an
unknown etiology. IBD is composed of two different disease entities: Crohn's disease (CD) …

Inflammatory bowel disease: exploring gut pathophysiology for novel therapeutic targets

V Yadav, F Varum, R Bravo, E Furrer, D Bojic… - Translational …, 2016 - Elsevier
Ulcerative colitis and Crohn's disease are the 2 major phenotypes of inflammatory bowel
disease (IBD), which are influenced by a complex interplay of immunological and genetic …

Current and emerging therapeutic targets for IBD

MF Neurath - Nature Reviews Gastroenterology & Hepatology, 2017 - nature.com
Various therapeutic advances have led to a paradigm shift in the clinical management of
patients with IBD. The introduction of immunosuppressive (such as azathioprine) and …

Evolving paradigms in the pathogenesis of IBD

L Mayer - Journal of gastroenterology, 2010 - Springer
The pathogenesis of all immune-mediated inflammatory diseases has been carefully studied
over the past several decades, but it is only recently that we have come to appreciate …

[HTML][HTML] Inflammatory bowel disease: emerging therapies and future treatment strategies

E Bretto, DG Ribaldone, GP Caviglia, GM Saracco… - Biomedicines, 2023 - mdpi.com
Inflammatory bowel disease (IBD) is a term used to represent a group of chronic, relapsing
inflammatory disorders of the gastrointestinal tract. Crohn's disease (CD) and ulcerative …

[HTML][HTML] Inflammatory bowel disease: past, present, and future

BE Sands - Journal of gastroenterology, 2007 - Springer
Crohn's disease and ulcerative colitis, collectively known as the inflammatory bowel
diseases (IBD), are largely diseases of the twentieth century, and are associated with the …

Biologic therapy for inflammatory bowel disease

S Ardizzone, GB Porro - Drugs, 2005 - Springer
Despite all of the advances in our understanding of the pathophysiology of inflammatory
bowel disease (IBD), we still do not know its cause. Some of the most recently available data …

Recent understanding of IBD pathogenesis: implications for future therapies

T Kucharzik, C Maaser, A Lügering… - Inflammatory bowel …, 2006 - academic.oup.com
The inflammatory bowel diseases (IBD) are comprised of two major phenotypes, Crohn's
disease (CD) and ulcerative colitis (UC). Research over the last couple of years has led to …

Future therapeutic approaches for inflammatory bowel diseases

SE Plevy, SR Targan - Gastroenterology, 2011 - Elsevier
In this review, we speculate about future therapeutic approaches for inflammatory bowel
diseases (IBDs), focusing on the need for better preclinical and clinical models and …