Granulins rescue inflammation, lysosome dysfunction, lipofuscin, and neuropathology in a mouse model of progranulin deficiency
J Root, A Mendsaikhan, G Taylor, P Merino, S Nandy… - Cell reports, 2024 - cell.com
Progranulin (PGRN) deficiency is linked to neurodegenerative diseases, including
frontotemporal dementia (FTD), Alzheimer's disease, and Parkinson's disease. Proper …
frontotemporal dementia (FTD), Alzheimer's disease, and Parkinson's disease. Proper …
[HTML][HTML] Granulins rescue inflammation, lysosome dysfunction, and neuropathology in a mouse model of progranulin deficiency
J Root, A Mendsaikhan, S Nandy, G Taylor, M Wang… - bioRxiv, 2023 - ncbi.nlm.nih.gov
Progranulin (PGRN) deficiency is linked to neurodegenerative diseases including
frontotemporal dementia, Alzheimer's disease, Parkinson's disease, and neuronal ceroid …
frontotemporal dementia, Alzheimer's disease, Parkinson's disease, and neuronal ceroid …
Network analysis of the progranulin-deficient mouse brain proteome reveals pathogenic mechanisms shared in human frontotemporal dementia caused by GRN …
Heterozygous, loss-of-function mutations in the granulin gene (GRN) encoding progranulin
(PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN …
(PGRN) are a common cause of frontotemporal dementia (FTD). Homozygous GRN …
A brain penetrant progranulin biotherapeutic rescues lysosomal and inflammatory phenotypes in the brain of GRN knockout mice: Lipids in AD and FTD: From genes …
T Logan, S DeVos, MJ Simon, S Davis… - Alzheimer's & …, 2020 - Wiley Online Library
Background Heterozygous loss of function (LOF) mutations in GRN cause frontotemporal
dementia (FTD), a neurodegenerative disorder associated with lysosomal dysfunction, TDP …
dementia (FTD), a neurodegenerative disorder associated with lysosomal dysfunction, TDP …
Identification of biological pathways regulated by PGRN and GRN peptide treatments using transcriptome analysis
S Rollinson, K Young… - European Journal of …, 2016 - Wiley Online Library
Mutations in progranulin (PGRN) have been linked to two neurodegenerative disorders,
heterozygote mutations with frontotemporal lobar degeneration (FTLD) and homozygote …
heterozygote mutations with frontotemporal lobar degeneration (FTLD) and homozygote …
Intracellular proteolysis of progranulin generates stable, lysosomal granulins that are haploinsufficient in patients with frontotemporal dementia caused by GRN …
Homozygous or heterozygous mutations in the GRN gene, encoding progranulin (PGRN),
cause neuronal ceroid lipofuscinosis (NCL) or frontotemporal dementia (FTD), respectively …
cause neuronal ceroid lipofuscinosis (NCL) or frontotemporal dementia (FTD), respectively …
A Novel In Vivo‐Active Small Molecule Inducer of Progranulin for the Treatment of Frontotemporal Dementia
JF Blain, AYP Chen, MA Brand, JC Lanter… - Alzheimer's & …, 2022 - Wiley Online Library
Background Heterozygous mutations in GRN that lead to haploinsufficiency of the
progranulin (PGRN) protein cause the fatal neurodegenerative disease frontotemporal …
progranulin (PGRN) protein cause the fatal neurodegenerative disease frontotemporal …
Selective depletion of microglial progranulin in mice is not sufficient to cause neuronal ceroid lipofuscinosis or neuroinflammation
TL Petkau, N Kosior, K de Asis, C Connolly… - Journal of …, 2017 - Springer
Background Progranulin deficiency due to heterozygous null mutations in the GRN gene are
a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous …
a common cause of familial frontotemporal lobar degeneration (FTLD), while homozygous …
[HTML][HTML] Microglia regulate brain progranulin levels through the endocytosis/lysosomal pathway
Genetic variants in Granulin (GRN), which encodes the secreted glycoprotein progranulin
(PGRN), are associated with several neurodegenerative diseases, including frontotemporal …
(PGRN), are associated with several neurodegenerative diseases, including frontotemporal …
Differential regulation of progranulin derived granulin peptides
Background Haploinsufficiency of progranulin (PGRN) is a leading cause of frontotemporal
lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed …
lobar degeneration (FTLD). PGRN is comprised of 7.5 granulin repeats and is processed …