During mitosis, the mitotic spindle is assembled to align chromosomes at the spindle
equator in metaphase, and to separate the genetic material equally to daughter cells in …

Microtubule‐based motor proteins play key roles during mitosis to assemble the bipolar
spindle, define the cell division axis, and align and segregate the chromosomes. The …

Kinesins are enzymes that use the energy of ATP to perform mechanical work. There are
approximately 14 families of kinesins within the kinesin superfamily. Family classification is …

Mitotic cell division is the most fundamental task of all living cells. Cells have intricate and
tightly regulated machinery to ensure that mitosis occurs with appropriate frequency and …

The failure of kinesin-targeting cancer drugs is thought to result from functional redundancy
of mitotic kinesins. A new study provides mechanistic insights into kinesin-12 that help to …

Members of the kinesin-8 motor family play a central role in controlling microtubule length
throughout the eukaryotic cell cycle. Inactivation of kinesin-8 causes defects in cell polarity …

Kinesin motor proteins comprise an ATPase superfamily that works hand in hand with
microtubules in every eukaryote. The mitotic kinesins, by virtue of their potential therapeutic …

Chromosome segregation during cell division requires a bipolar mitotic spindle. Therefore,
how the spindle is formed, maintained, and functions is of fundamental importance for all …

Microtubules are essential for intracellular transport, cell motility, spindle assembly, and
chromosome segregation during cell division. Microtubule dynamics regulate the proper …

Proper regulation of microtubules (MTs) is critical for the execution of diverse cellular
processes, including mitotic spindle assembly and chromosome segregation. There are a …