Most cancers emerge in elderly and immune-comprised hosts implying an important role for
cancer immune surveillance. Here, we focus on the role of tissue-associated innate immune …

Improvements in understanding cancer immunopathogenesis have now led to
unprecedented successes in immunotherapy to treat numerous cancers. Although aging is …

The progression of physiological ageing is driven by intracellular aberrations including
telomere attrition, genomic instability, epigenetic alterations and loss of proteostasis. These …

Most cancers emerge in the elderly, including lung cancer and mesothelioma, yet the elderly
remain an underrepresented population in pre-clinical cancer studies and clinical trials. The …

Therapy-induced cellular senescence is a state of stable growth arrest induced by common
cancer treatments such as chemotherapy and radiation. In an oncogenic context, therapy …

The etiology and effect of age-related immune dysfunction in cancer is not completely
understood. Here we show that limited priming of CD8+ T cells in the aged tumor …

Impaired immune function has been implicated in the declining health and higher incidence
of cancer in the elderly. However, age-related changes to immunity are not completely …

Simple Summary Senescent T cells are defective in proliferation and effector functions, and
they accumulate owing to aging, chronic viral infections, and autoimmune diseases. Several …

The functional state of the preexisting T cells in the tumor microenvironment is a key
determinant for effective antitumor immunity and immunotherapy. Increasing evidence …

Background Aging has long been thought to be a major risk factor for various types of
cancers. However, accumulating evidence indicates increased resistance of old animals to …