The recent discovery that TMEM106B serves as a receptor mediating ACE2-independent
SARS-CoV-2 entry into cells deserves attention, especially in the background of the frequent …

SARS-CoV-2 is associated with broad tissue tropism, a characteristic often determined by
the availability of entry receptors on host cells. Here, we show that TMEM106B, a lysosomal …

SARS-CoV-2 has a broad tissue tropism. In Cell, Baggen et al. show that the lysosomal
transmembrane protein TMEM106B directly engages the receptor-binding domain (RBD) of …

The lysosomal membrane protein TMEM106B functions as a proviral factor in SARS-CoV-2
infection, though it was not known how. In this issue of Cell, Baggen et al. demonstrate that …

Antiviral therapeutics are a front-line defense against virally induced diseases. Because
viruses frequently mutate to escape direct inhibition of viral proteins, there is interest in …

Recently, severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) variant B. 1.1.
529 (Omicron) has rapidly become the dominant strain, with an unprecedented number of …

The frequently emerging SARS-CoV-2 variants have weakened the effectiveness of existing
COVID-19 vaccines and neutralizing antibody therapy. Nevertheless, the infections of SARS …

There is an urgent need for animal models to study SARS-CoV-2 pathogenicity. Here, we
generate and characterize a novel mouse-adapted SARS-CoV-2 strain, MASCp36, that …

Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) has caused a global
pandemic. Angiotensin-converting enzyme 2 (ACE2) is an entry receptor for SARS-CoV-2 …

Dear Editor, The continued spread of severe acute respiratory syndrome coronavirus 2
(SARS-CoV-2) Omicron variants has caught another wave of COVID-19 pandemic and …