Kidney injury molecule-1: a novel entry factor for SARS-CoV-2

C Wan, C Zhang - Journal of Molecular Cell Biology, 2021 - academic.oup.com
Renal involvement occurs frequently among patients with coronavirus disease 2019 (COVID-
19) caused by severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), and acute …

Structures of the Omicron spike trimer with ACE2 and an anti-Omicron antibody: mechanisms for the high infectivity, immune evasion and antibody drug discovery

W Yin, Y Xu, P Xu, X Cao, C Wu, C Gu, X He, X Wang… - bioRxiv, 2021 - biorxiv.org
The Omicron variant of SARS-CoV-2 has rapidly become the dominant infective strain and
the focus efforts against the ongoing COVID-19 pandemic. Here we report an extensive set …

The Omicron (B. 1.1. 529) variant of SARS-CoV-2 binds to the hACE2 receptor more strongly and escapes the antibody response: Insights from structural and …

A Khan, H Waris, M Rafique, M Suleman… - International journal of …, 2022 - Elsevier
Abstract As SARS-CoV-2 (severe acute respiratory syndrome coronavirus 2) continues to
inflict chaos globally, a new variant officially known as B. 1.1. 529 was reported in South …

Key residues of the receptor binding domain in the spike protein of SARS-CoV-2 mediating the interactions with ACE2: a molecular dynamics study

Y Yang, Y Zhang, Y Qu, C Zhang, XW Liu, M Zhao… - Nanoscale, 2021 - pubs.rsc.org
The widespread coronavirus disease 2019 (COVID-19) has been declared a global health
emergency. As one of the most important targets for antibody and drug developments, the …

Comparative analysis reveals the species-specific genetic determinants of ACE2 required for SARS-CoV-2 entry

W Ren, Y Zhu, Y Wang, H Shi, Y Yu, G Hu… - PLoS …, 2021 - journals.plos.org
Coronavirus interaction with its viral receptor is a primary genetic determinant of host range
and tissue tropism. SARS-CoV-2 utilizes ACE2 as the receptor to enter host cell in a species …

[HTML][HTML] The ACE2-binding interface of SARS-CoV-2 Spike inherently deflects immune recognition

T Hattori, A Koide, MG Noval, T Panchenko… - Journal of molecular …, 2021 - Elsevier
The COVID-19 pandemic remains a global threat, and host immunity remains the main
mechanism of protection against the disease. The spike protein on the surface of SARS-CoV …

Structural insights into the Omicron spike trimer: tackling the challenges of continuously evolving SARS-CoV-2 variants

J Ou, J Wu, Q Zhang - Signal Transduction and Targeted Therapy, 2022 - nature.com
The recent studies published in Science and Cell Research investigated the structures and
biochemical mechanism of the SARS-CoV-2 Omicron BA. 1 and BA. 2 spike trimer with …

Discovery and evaluation of entry inhibitors for SARS-CoV-2 and its emerging variants

A Acharya, K Pandey, M Thurman, E Klug… - Journal of …, 2021 - Am Soc Microbiol
The outbreak of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) is
responsible for the coronavirus disease 19 (COVID-19) pandemic. Despite unprecedented …

Membrane nanoparticles derived from ACE2-rich cells block SARS-CoV-2 infection

C Wang, S Wang, Y Chen, J Zhao, S Han, G Zhao… - ACS …, 2021 - ACS Publications
The ongoing COVID-19 pandemic worldwide necessitates the development of therapeutics
against SARS-CoV-2. ACE2 is the main receptor of SARS-CoV-2 S1 and mediates viral …

[HTML][HTML] Structural and functional characterizations of infectivity and immune evasion of SARS-CoV-2 Omicron

Z Cui, P Liu, N Wang, L Wang, K Fan, Q Zhu, K Wang… - Cell, 2022 - cell.com
Summary The SARS-CoV-2 Omicron variant with increased fitness is spreading rapidly
worldwide. Analysis of cryo-EM structures of the spike (S) from Omicron reveals amino acid …