RNA sequencing (RNA-seq) provides an efficient high-throughput technique to robustly
characterize the tumor immune microenvironment (TME). The increasing use of RNA-seq in …

Abstract RNA-sequencing (RNA-seq) has become an increasingly cost-effective technique
for molecular profiling and immune characterization of tumors. In the past decade, many …

The rising interest for precise characterization of the tumour immune contexture has recently
brought forward the high potential of RNA sequencing (RNA-seq) in identifying molecular …

The clinical success of immune checkpoint blockade provides great hope for curing cancers.
However, the patient responses are not even. Precise understanding of tumor immunity is …

Understanding tumor immune microenvironments is critical for identifying immune modifiers
of cancer progression and developing cancer immunotherapies. Recent applications of …

Tumor-infiltrating immune cells comprise various cells of the innate and the adaptive
immune system, which influence tumor growth and response to immunotherapy by exerting …

Cancer immunotherapy targeting co-inhibitory pathways by checkpoint blockade shows
remarkable efficacy in a variety of cancer types. However, only a minority of patients respond …

Motivation The composition and density of immune cells in the tumor microenvironment
(TME) profoundly influence tumor progression and success of anti-cancer therapies. Flow …

Immunotherapies such as immune checkpoint blockade and adoptive cell transfer have
revolutionized cancer treatment, but further progress is hindered by our limited …

By exerting pro-and anti-tumorigenic actions, tumor-infiltrating immune cells can profoundly
influence tumor progression, as well as the success of anti-cancer therapies. Therefore, the …