Deficiency in the membrane cytoskeletal protein dystrophin is the underlying cause of the
progressive muscle wasting disease named Duchenne muscular dystrophy. In order to …

Dystrophin is a long rod-shaped protein that connects the subsarcolemmal cytoskeleton to a
complex of proteins in the surface membrane (dystrophin protein complex, DPC), with further …

Duchenne muscular dystrophy (DMD) is an X-linked muscle-wasting disease caused by the
loss of dystrophin. DMD is associated with muscle degeneration, necrosis, inflammation …

The X-linked muscle-wasting disease Duchenne muscular dystrophy is caused by mutations
in the gene encoding dystrophin. There is currently no effective treatment for the disease; …

The almost complete loss of the membrane cytoskeletal protein dystrophin and concomitant
drastic reduction in dystrophin-associated glycoproteins are the underlying mechanisms of …

This perspective article is concerned with the question of how proteomics, which is a core
technique of systems biology that is deeply embedded in the multi-omics field of modern …

The systematic bioanalytical characterization of the protein product of the DMD gene, which
is defective in the pediatric disorder Duchenne muscular dystrophy, led to the discovery of …

The optimization of large-scale screening procedures of pathological specimens by
genomic, proteomic and metabolic methods has drastically increased the bioanalytical …

The dystrophin–glycoprotein complex (DGC) can be considered as a specialized adhesion
complex, linking the extracellular matrix to the actin cytoskeleton, primarily in muscle cells …

The highly progressive neuromuscular disorder dystrophinopathy is triggered by primary
abnormalities in the Dmd gene, which causes cytoskeletal instability and loss of …