Immunotherapies for the treatment of uveal melanoma—history and future

TE Schank, JC Hassel - Cancers, 2019 - mdpi.com
Background: Uveal melanoma is the most common primary intraocular malignancy among
adults. It is, nevertheless, a rare disease, with an incidence of approximately one case per …

Immunotherapy for uveal melanoma-current knowledge and perspectives

S Kaštelan, AG Antunica, LB Oresković… - Current medicinal …, 2020 - ingentaconnect.com
Uveal melanoma is the most prevalent primary intraocular tumour in adults with the
incidence between five and six cases per million people in the United States and Europe …

Immunological backbone of uveal melanoma: is there a rationale for immunotherapy?

E Rossi, G Schinzari, IG Zizzari, BA Maiorano… - Cancers, 2019 - mdpi.com
No standard treatment has been established for metastatic uveal melanoma (mUM).
Immunotherapy is commonly used for this disease even though UM has not been included …

Immunotherapy for the treatment of uveal melanoma: current status and emerging therapies

KM Komatsubara, RD Carvajal - Current oncology reports, 2017 - Springer
Abstract Purpose of Review Uveal melanoma is a distinct subset of melanoma with a biology
and treatment approach that is unique from that of cutaneous melanoma. Here we will …

Immunotherapy in uveal melanoma: novel strategies and opportunities for personalized treatment

C Masaoutis, S Kokkali… - Expert opinion on …, 2021 - Taylor & Francis
Introduction Uveal melanoma (UM) is the most common intraocular cancer and represents a
discrete subtype of melanoma. Metastatic disease, which occurs in half of patients, has a …

Treatment of uveal melanoma: where are we now?

J Yang, DK Manson, BP Marr… - … advances in medical …, 2018 - journals.sagepub.com
Uveal melanoma, a rare subset of melanoma, is the most common primary intraocular
malignancy in adults. Despite effective primary therapy, nearly 50% of patients will develop …

Recent advances and challenges in uveal melanoma immunotherapy

Y Fu, W Xiao, Y Mao - Cancers, 2022 - mdpi.com
Simple Summary Uveal melanoma is the most common primary intraocular malignancy in
adults. Although it can be controlled locally, half of the patients still develop metastases. To …

Nivolumab and ipilimumab in metastatic uveal melanoma: results from a single-arm phase II study

MS Pelster, SK Gruschkus, R Bassett… - Journal of Clinical …, 2021 - ascopubs.org
PURPOSE Metastatic uveal melanoma has poor overall survival (OS) and no approved
systemic therapy options. Studies of single-agent immunotherapy regimens have shown …

Real-world impact of immune checkpoint inhibitors in metastatic uveal melanoma

KF Bol, E Ellebaek, L Hoejberg, MM Bagger… - Cancers, 2019 - mdpi.com
Uveal melanoma (UM) is the most common intraocular malignancy in adults and shows a
high rate of metastatic spread. As randomized clinical trials with immune checkpoint …

Anti‐PD‐1 antibodies in metastatic uveal melanoma: a treatment option?

C Bender, A Enk, R Gutzmer, JC Hassel - Cancer medicine, 2017 - Wiley Online Library
Uveal melanomas (UM s) are a rare form of cancer with clinical and pathological
characteristics distinct from cutaneous melanomas. Ipilimumab has shown efficacy and …