Control of gene transcription by glucocorticoid receptors (GRs) is important for many
physiological processes. Like other steroid hormone receptors, the regulation of target …

The precise mechanism by which glucocorticoid receptor (GR) regulates the transcription of
its target genes is largely unknown. This is, in part, due to the lack of structural and functional …

Despite their importance in gene regulation, the exact mechanisms of glucocorticoid
receptor's (GR's) N-terminal activation function region, AF1, which exists in an intrinsically …

Steroid hormone receptors are members of a family of ligand inducible transcription factors,
and regulate the transcriptional activation of target genes by recruiting coregulatory proteins …

Intrinsically disordered (ID) regions of proteins commonly exist within transcription factors,
including the N-terminal domain (NTD) of steroid hormone receptors (SHRs) that possesses …

The glucocorticoid receptor (GR) mediates biological effects of glucocorticoids at the level of
gene regulation, and plays important roles in many aspects of physiology. In recent years, it …

Intrinsically disordered (ID) regions of the transcription factor proteins have much larger
frequency of phosphorylation sites than ordered regions, suggesting an important role in …

Steroid hormones are important endocrine signalling molecules controlling reproduction,
development, metabolism, salt balance and specialized cellular responses, such as …

Both agonist-and antagonist-bound glucocorticoid receptors (GRs) and progesterone
receptors (PRs) regulate gene transcription with the assistance of corepressors (NCoR and …

A number of transcription factor proteins contain domains that are fully or partially
unstructured. The means by which such proteins acquire naturally folded conformations are …