During the brain development, the process of neural stem cells (NSCs) proliferation and
differentiation is precisely regulated. The deficiency in the embryonic brain development will …

Early neurodevelopment requires cell fate commitment from pluripotent stem cells to
restricted neural lineages, which involves the epigenetic regulation of chromatin structure …

During embryonic brain development, neurogenesis requires the orchestration of gene
expression to regulate neural stem cell (NSC) fate specification. Epigenetic regulation with …

Defects in neurogenesis alter brain circuit formations and may lead to neurodevelopmental
disorders such as autism and schizophrenia. Histone H2A. z, a variant of histone H2A, plays …

Histone variants, which can be expressed outside of S-phase and deposited DNA synthesis-
independently, provide long-term histone replacement in postmitotic cells, including …

Astrocytes play crucial roles in the central nervous system, and defects in astrocyte function
are closely related to many neurological disorders. Studying the mechanism of gliogenesis …

Abstract Background Neural tube defects (NTDs) are severe, common birth defects that
result from failure of normal neural tube closure during early embryogenesis. Accumulating …

Neurons are a key component of the nervous system and differentiate from multipotent
neural stem cells (NSCs). Chromatin remodeling has a critical role in the differentiation …

Neuroectoderm is an important neural precursor. However, chromatin remodeling and its
epigenetic regulatory roles during the differentiation of human neuroectodermal cells …

Point mutations within the histone H3. 3 are frequent in aggressive childhood brain tumors
known as pediatric high-grade gliomas (pHGGs). Intriguingly, distinct mutations arise in …