Heterotopic ossification (HO) is a debilitating condition defined by the de novo development
of bone within non-osseous soft tissues, and can be either hereditary or acquired. The …

Heterotopic ossification is characterized by the formation of normal bone at ectopic soft‐
tissue locations. Regardless of the etiology of heterotopic ossification, requisite pathogenetic …

Put most simply, heterotopic ossification (HO) is the abnormal formation of bone at
extraskeletal sites. HO can be classified into two main subtypes, genetic and acquired …

Heterotopic ossification is defined as an aberrant formation of bone in extraskeletal soft
tissue, for which both genetic and acquired conditions are known. This pathologic process …

Educational Objectives As a result of reading this article, physicians should be able to: 1.
Update the current knowledge about candidate cell populations as heterotopic ossification …

Nonhereditary heterotopic ossification (NHHO) usually arises in the setting of trauma, certain
arthropathies, or following injury, often in the setting of common age-related conditions. In …

Heterotopic ossification (HO), the abnormal formation of true marrow-containing bone within
extraskeletal soft tissues, is a serious bony disorder that may be either acquired or …

Heterotopic ossification, the formation of bone in soft tissue, requires inductive signaling
pathways, inducible osteoprogenitor cells, and a heterotopic environment conducive to …

Heterotopic ossification (HO) is a diverse pathologic process, defined as the formation of
extraskeletal bone in muscle and soft tissues. HO can be conceptualized as a tissue repair …

Heterotopic ossification (HO) is a process by which bone forms in soft tissues, in response to
injury, inflammation, or genetic disease. This usually occurs by initial cartilage formation …