Therapeutic potential of SARS-CoV-2-specific monoclonal antibody CR3022

C Atyeo, MD Slein, S Fischinger, J Burke, A Schӓfer… - 2020 - papers.ssrn.com
The spread of the severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), coupled
with a lack of therapeutics or vaccines, has paralyzed the globe. While significant effort has …

[HTML][HTML] Dissecting strategies to tune the therapeutic potential of SARS-CoV-2–specific monoclonal antibody CR3022

C Atyeo, MD Slein, S Fischinger, J Burke, A Schäfer… - JCI insight, 2021 - ncbi.nlm.nih.gov
The rapid spread of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2),
coupled with a lack of therapeutics, has paralyzed the globe. Although significant effort has …

Fc-independent neutralization of SARS-CoV-2 by recombinant human monoclonal antibodies

T Noy-Porat, A Edri, R Alcalay, E Makdasi, D Gur… - bioRxiv, 2021 - biorxiv.org
The use of passively-administered neutralizing antibodies is a promising approach for the
prevention and treatment of SARS-CoV-2 infection. Antibody-mediated protection may …

Evaluation of strategies to modify Anti-SARS-CoV-2 monoclonal antibodies for optimal functionality as therapeutics

RV House, TA Broge, TJ Suscovich, DM Snow… - PloS one, 2022 - journals.plos.org
The current global COVID-19 pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has resulted in a public health crisis with more than 168 million …

The Fc-mediated effector functions of a potent SARS-CoV-2 neutralizing antibody, SC31, isolated from an early convalescent COVID-19 patient, are essential for the …

CEZ Chan, SGK Seah, DH Chye, S Massey, M Torres… - PLoS …, 2021 - journals.plos.org
Although SARS-CoV-2-neutralizing antibodies are promising therapeutics against COVID-
19, little is known about their mechanism (s) of action or effective dosing windows. We report …

The variable conversion of neutralizing anti-SARS-CoV-2 single-chain antibodies to IgG provides insight into RBD epitope accessibility

MR Chang, H Ke, L Losada Miguéns… - Protein Engineering …, 2023 - academic.oup.com
Monoclonal antibody (mAb) therapies have rapidly become a powerful class of therapeutics
with applications covering a diverse range of clinical indications. Though most widely used …

Beyond neutralization: Fc-dependent antibody effector functions in SARS-CoV-2 infection

A Zhang, HD Stacey, MR D'Agostino, Y Tugg… - Nature Reviews …, 2023 - nature.com
Neutralizing antibodies are known to have a crucial role in protecting against SARS-CoV-2
infection and have been suggested to be a useful correlate of protection for vaccine clinical …

Research progress in Fc‐effector functions against SARS‐CoV‐2

R Gao, C Feng, Z Sheng, F Li… - Journal of Medical …, 2024 - Wiley Online Library
The severe acute respiratory syndrome coronavirus 2 (SARS‐CoV‐2) pandemic has caused
more than 676 million cases in the global human population with approximately 7 million …

Deciphering Fc-effector functions against SARS-CoV-2

G Beaudoin-Bussières, A Finzi - Trends in Microbiology, 2024 - cell.com
Major efforts were deployed to study the antibody response against SARS-CoV-2.
Antibodies neutralizing SARS-CoV-2 have been extensively studied in the context of …

Fc-engineered antibody therapeutics with improved efficacy against COVID-19

J Ravetch, R Yamin, A Jones, HH Hoffmann… - Research …, 2021 - researchsquare.com
Monoclonal antibodies (mAbs) with neutralizing activity against SARS-CoV-2 have
demonstrated clinical benefit in cases of mild to moderate SARS-CoV-2 infection …