Significant bone loss due to disease or severe injury can result in the need for a bone graft,
with over 500,000 procedures occurring each year in the United States. However, the …

Description Bone loss and skeletal deficiencies due to traumatic injury or disease are major
problems worldwide. In the US, approximately 500,000 bone-grafting procedures are …

Bone is one of the most vascular network-rich tissues in the body and the vascular system is
essential for the development, homeostasis, and regeneration of bone. When segmental …

There is a profound need for orthopaedic grafting strategies due to various trauma and
musculoskeletal diseases. Tissue engineering offers a promising avenue to develop viable …

Obtaining functional capillaries through the bulk has been identified as a major challenge in
tissue engineering, particularly for critical-sized defects. In the present study, a multilayered …

Bone tissue is a highly vascularized tissue and concomitant development of the vascular
system and mineralized matrix requires a synergistic interaction between osteogenesis and …

Vascularization of engineered bone tissue is critical for ensuring its survival after
implantation. In vitro pre-vascularization of bone grafts with endothelial cells is a promising …

The bone defect caused by fracture, bone tumor, infection, and other causes is not only a
problematic point in clinical treatment but also one of the hot issues in current research. The …

Bone tissue engineering (BTE) aims to improve the healing of bone fractures using scaffolds
that mimic the native extracellular matrix. For successful bone regeneration, scaffolds should …

Bone tissue engineering approaches have evolved towards addressing the challenges of
tissue mimetic requirements over the years. Different strategies have been combining …