Abstract Phosphoinositide 3-kinase (PI3K) belongs to the intracellular lipid kinases family
involved in diverse physiological processes, including proliferation, apoptosis, growth, and …

Colorectal cancer (CRC) remains one of the leading causes of cancer mortality worldwide.
Regarded as a heterogeneous disease, a number of biomarkers have been proposed to …

Survival times of patients with colorectal cancer (CRC) have increased over the past
decade, primarily as a result of treatment with combinations of conventional cytotoxic agents …

In the last decade treatment for colorectal cancer (CRC) has evolved with the addition of
contemporary chemotherapy drugs and targeted therapies. Despite this progress, our drug …

Background: Phosphoinositide 3-kinase (PI3Ks) is a member of intracellular lipid kinases
and involved in the regulation of cellular proliferation, differentiation and survival …

Colorectal cancer (CRC) is one of the leading causes of cancer-related death in the USA,
and more effective treatment of CRC is therefore needed. Advances in our understanding of …

The PI3K/AKT pathway plays a pivotal role in cellular processes, and its dysregulation is
implicated in various cancers, including colorectal cancer. The present study correlates the …

Zusammenfassung Die Phosphoinositol-3-OH-Kinase (PI3K) und die von ihr aktivierte
Serin/Threoninkinase Akt, auch als Proteinkinase B bekannt, sind wichtige Effektormoleküle …

The pathophysiology of colorectal cancer (CRC) has not been fully elucidated. The
dysregulation of the phosphatidylinositol 3‑kinase (PI3K) signaling pathway frequently …

Abstract PI3K/AKT signaling leads to reduced apoptosis, stimulates cell growth and
increases proliferation. Under normal conditions, PI3K/AKT activation is tightly controlled …