Tendon-derived stem cells (TDSCs): from basic science to potential roles in tendon pathology and tissue engineering applications

PPY Lui, KM Chan - Stem cell reviews and reports, 2011 - Springer
Traditionally, tendons are considered to only contain tenocytes that are responsible for the
maintenance, repair and remodeling of tendons. Stem cells, which are termed tendon …

Identity of tendon stem cells–how much do we know?

PPY Lui - Journal of cellular and molecular medicine, 2013 - Wiley Online Library
Tendon stem cells are multi‐potent adult stem cells with broad differentiation plasticity that
render them of great importance in cell‐based therapies for the repair of tendons. We called …

Markers for the identification of tendon-derived stem cells in vitro and tendon stem cells in situ–update and future development

PPY Lui - Stem cell research & therapy, 2015 - Springer
The efficacy of tendon-derived stem cells (TDSCs) for the promotion of tendon and tendon-
bone junction repair has been reported in animal studies. Modulation of the tendon stem cell …

Tendon stem/progenitor cell subpopulations and their implications in tendon biology

Z Huang, Z Yin, J Xu, Y Fei, BC Heng… - Frontiers in Cell and …, 2021 - frontiersin.org
Tendon harbors a cell population that possesses stem cell characteristics such as
clonogenicity, multipotency and self-renewal capacity, commonly referred to as tendon …

Characterization of differential properties of rabbit tendon stem cells and tenocytes

J Zhang, JHC Wang - BMC musculoskeletal disorders, 2010 - Springer
Background Tendons are traditionally thought to consist of tenocytes only, the resident cells
of tendons; however, a recent study has demonstrated that human and mouse tendons also …

The functions and mechanisms of tendon stem/progenitor cells in tendon healing

J Lu, H Chen, K Lyu, L Jiang, Y Chen… - Stem Cells …, 2023 - Wiley Online Library
Tendon injury is one of the prevalent disorders of the musculoskeletal system in orthopedics
and is characterized by pain and limitation of joint function. Due to the difficulty of …

Identification and distinction of tenocytes and tendon-derived stem cells

Y Li, T Wu, S Liu - Frontiers in Cell and Developmental Biology, 2021 - frontiersin.org
Restoring the normal structure and function of injured tendons is one of the biggest
challenges in orthopedics and sports medicine department. The discovery of tendon-derived …

A comparison of the stem cell characteristics of murine tenocytes and tendon-derived stem cells

KJ Lee, PD Clegg, EJ Comerford… - BMC Musculoskeletal …, 2018 - Springer
Tendon is a commonly injured soft musculoskeletal tissue, however, poor healing potential
and ineffective treatment strategies result in persistent injuries and tissue that is unable to …

Tendon stem progenitor cells: Understanding the biology to inform therapeutic strategies for tendon repair

B Walia, AH Huang - Journal of Orthopaedic Research®, 2019 - Wiley Online Library
Tendon and ligament injuries are a leading cause of healthcare visits with significant impact
in terms of economic cost and reduced quality of life. To date, reparative strategies remain …

[HTML][HTML] Tendon stem cells: experimental and clinical perspectives in tendon and tendon-bone junction repair

PPY Lui, OT Wong - Muscles, ligaments and tendons journal, 2012 - ncbi.nlm.nih.gov
Tendon and tendon-bone junction injuries, while heal, have high re-tear rates.
Mesenchymal stem cells (MSCs) have great appeal for the promotion of tendon and tendon …