The CRISPR-Cas system is commonly known for its ability to cleave DNA in a
programmable manner, which has democratized gene editing and facilitated recent …

Since the revolutionary discovery of the CRISPR-Cas technology for programmable genome
editing, its range of applications has been extended by multiple biotechnological tools that …

The recent development of CRISPR–Cas systems as easily accessible and programmable
tools for genome editing and regulation is spurring a revolution in biology. Paired with the …

The discovery and adaption of bacterial clustered regularly interspaced short palindromic
repeats (CRISPR)–CRISPR-associated (Cas) systems has revolutionized the way …

Targeted genome editing using engineered nucleases has rapidly gone from being a niche
technology to a mainstream method used by many biological researchers. This widespread …

Background Clustered regularly interspaced short palindromic repeat (CRISPR)-CRISPR-
associated protein (Cas) systems are the latest addition to the plethora of gene-editing tools …

The diversity, modularity, and efficacy of CRISPR-Cas systems are driving a
biotechnological revolution. RNA-guided Cas enzymes have been adopted as tools to …

The prokaryote-derived CRISPR–Cas genome editing systems have transformed our ability
to manipulate, detect, image and annotate specific DNA and RNA sequences in living cells …

Targeted genome editing using engineered nucleases has rapidly transformed from a niche
technology to a mainstream method used by many biological researchers. This widespread …

Class 2 CRISPR–Cas systems, such as Cas9 and Cas12, have been widely used to target
DNA sequences in eukaryotic genomes. However, class 1 CRISPR–Cas systems, which …