In this study, we examined pathophysiological roles of osteoactivin, a functionally unknown
type I membrane glycoprotein, in mouse skeletal muscle atrophied by denervation (sciatic …

We have previously shown that osteoactivin, a type I membrane glycoprotein expressed in
myofibers, upregulated expression of matrix metalloprotease (MMP)-3 and MMP-9 in …

Osteoactivin (OA) is a novel osteogenic factor important for osteoblast differentiation and
function. Previous studies showed that OA stimulates matrix mineralization and transcription …

Intact osteoactivin, a novel type I membrane glycoprotein, were shed at a dibasic motif in the
juxtamembrane region in C2C12 myoblasts. Extracellular fragments were secreted into the …

We previously identified osteoactivin (OA) as a novel secreted osteogenic factor with high
expression in developing long bones and calvaria, and that stimulates osteoblast …

Osteoblast development is a complex process involving the expression of specific growth
factors and regulatory proteins that control cell proliferation, differentiation, and maturation …

Osteoactivin is a heavily glycosylated protein shown to have a role in bone remodeling.
Previous studies from our lab have shown that mutation in Osteoactivin enhances osteoclast …

Initial identification of osteoactivin (OA)/glycoprotein non‐melanoma clone B (gpnmb) was
demonstrated in an osteopetrotic rat model, where OA expression was increased threefold …

This study presents gene expression, protein expression, and in situ immunohistochemical
evidence that osteoclasts express high levels of osteoactivin (OA), which had previously …

Our laboratory previously showed that osteoactivin (OA) is a novel, osteoblast‐related
glycoprotein that plays a role in osteoblast differentiation and function. The purpose of this …