The major signaling pathways regulating gastric stem cells are unknown. Here we report
that Notch signaling is essential for homeostasis of LGR 5+ antral stem cells. Pathway …

The mammalian adult gastric epithelium self-renews continually through the activity of stem
cells located in the isthmus of individual gland units. Mechanisms facilitating stomach stem …

Background & Aims Notch pathway signaling maintains gastric epithelial cell homeostasis
by regulating stem cell proliferation and differentiation. We previously identified NOTCH1 …

The gastric epithelium is sustained by a population of stem cells that replenish the various
mature epithelial lineages throughout adulthood. Regulation of stem and progenitor cell …

Notch pathway signaling is known to promote gastric stem cell proliferation, and constitutive
pathway activation induces gastric tumors via mTORC1 activation in mouse genetic models …

The Notch signaling pathway is known to regulate stem cells and epithelial cell homeostasis
in gastrointestinal tissues; however, Notch function in the corpus region of the stomach is …

Objective We tested the ability of Notch pathway receptors Notch1 and Notch2 to regulate
stem and epithelial cell homoeostasis in mouse and human gastric antral tissue. Design …

The gastrointestinal (GI) tract epithelium is continuously replenished by actively cycling stem
and progenitor cells. These cell compartments are regulated to balance proliferation and …

The glandular stomach is composed of two regenerative compartments termed corpus and
antrum, and our understanding of the transcriptional networks that maintain these tissues is …

Notch signaling, an evolutionarily conserved signaling cascade system, is involved in
promoting the progression of different types of cancers. Within the past decades, the Notch …