Brain parenchymal and extraparenchymal macrophages in development, homeostasis, and disease

S Brioschi, Y Zhou, M Colonna - The Journal of Immunology, 2020 - journals.aai.org
Microglia are parenchymal macrophages of the CNS; as professional phagocytes they are
important for maintenance of the brain's physiology. These cells are generated through …

Microglia and macrophages in brain homeostasis and disease

Q Li, BA Barres - Nature Reviews Immunology, 2018 - nature.com
Microglia and non-parenchymal macrophages in the brain are mononuclear phagocytes that
are increasingly recognized to be essential players in the development, homeostasis and …

Development and maintenance of the brain's immune toolkit: Microglia and non‐parenchymal brain macrophages

JP Lopez‐Atalaya, KE Askew, A Sierra… - Developmental …, 2018 - Wiley Online Library
Microglia and non‐parenchymal macrophages located in the perivascular space, the
meninges and the choroid plexus are independent immune populations that play vital roles …

Microglia and central nervous system–associated macrophages—from origin to disease modulation

M Prinz, T Masuda, MA Wheeler… - Annual review of …, 2021 - annualreviews.org
The immune system of the central nervous system (CNS) consists primarily of innate
immune cells. These are highly specialized macrophages found either in the parenchyma …

Microglia: unique and common features with other tissue macrophages

M Prinz, TL Tay, Y Wolf, S Jung - Acta neuropathologica, 2014 - Springer
Microglia are highly specialized tissue macrophages of the brain with dedicated functions in
neuronal development, homeostasis and recovery from pathology Despite their unique …

[HTML][HTML] Origin and emergence of microglia in the CNS—an interesting (Hi) story of an eccentric cell

I Dermitzakis, ME Manthou, S Meditskou… - Current issues in …, 2023 - mdpi.com
Microglia belong to tissue-resident macrophages of the central nervous system (CNS),
representing the primary innate immune cells. This cell type constitutes~ 7% of non …

[HTML][HTML] Microglia versus myeloid cell nomenclature during brain inflammation

M Greter, I Lelios, AL Croxford - Frontiers in immunology, 2015 - frontiersin.org
As immune sentinels of the central nervous system (CNS), microglia not only respond
rapidly to pathological conditions but also contribute to homeostasis in the healthy brain. In …

Microglia and brain macrophages in the molecular age: from origin to neuropsychiatric disease

M Prinz, J Priller - Nature Reviews Neuroscience, 2014 - nature.com
Mononuclear phagocytic cells in the CNS used to be defined according to their anatomical
location and surface marker expression. Recently, this concept has been challenged by the …

Microglia in Health and Diseases: Integrative Hubs of the Central Nervous System (CNS)

A Sierra, VE Miron, RC Paolicelli… - Cold Spring Harbor …, 2024 - cshperspectives.cshlp.org
Microglia are usually referred to as “the innate immune cells of the brain,”“the resident
macrophages of the central nervous system”(CNS), or “CNS parenchymal macrophages.” …

Microglia across the lifespan: from origin to function in brain development, plasticity and cognition

TL Tay, JC Savage, CW Hui, K Bisht… - The Journal of …, 2017 - Wiley Online Library
Microglia are the only immune cells that permanently reside in the central nervous system
(CNS) alongside neurons and other types of glial cells. The past decade has witnessed a …