Inhibition of interleukin 1 receptor/Toll-like receptor signaling through the alternatively spliced, short form of MyD88 is due to its failure to recruit IRAK-4
K Burns, S Janssens, B Brissoni, N Olivos… - The Journal of …, 2003 - rupress.org
Toll-like receptors (TLRs) and members of the proinflammatory interleukin 1 receptor (IL-1R)
family are dependent on the presence of MyD88 for efficient signal transduction. The …
family are dependent on the presence of MyD88 for efficient signal transduction. The …
A dimer of the Toll-like receptor 4 cytoplasmic domain provides a specific scaffold for the recruitment of signalling adaptor proteins
R Núñez Miguel, J Wong, JF Westoll, HJ Brooks… - PloS one, 2007 - journals.plos.org
The Toll-like receptor 4 (TLR4) is a class I transmembrane receptor expressed on the
surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides …
surface of immune system cells. TLR4 is activated by exposure to lipopolysaccharides …
Triad3A, an E3 ubiquitin-protein ligase regulating Toll-like receptors
TH Chuang, RJ Ulevitch - Nature immunology, 2004 - nature.com
Activation of Toll-like receptors (TLRs) results in a proinflammatory response needed to
combat infection. Thus, limiting TLR signaling is essential for preventing a protective …
combat infection. Thus, limiting TLR signaling is essential for preventing a protective …
Toll-like receptor gene family and TIR-domain adapters in Danio rerio
C Jault, L Pichon, J Chluba - Molecular immunology, 2004 - Elsevier
The toll-like family of receptors (TLR) is an ancient pattern recognition receptor family,
conserved from insects to mammals. We have identified in zebrafish (Danio rerio) 19 …
conserved from insects to mammals. We have identified in zebrafish (Danio rerio) 19 …
Interactive sites in the MyD88 Toll/interleukin (IL) 1 receptor domain responsible for coupling to the IL1β signaling pathway
Myeloid differentiation factor MyD88 is the essential adaptor protein that integrates and
transduces intracellular signals generated by multiple Toll-like receptors including receptor …
transduces intracellular signals generated by multiple Toll-like receptors including receptor …
Identification of critical residues of the MyD88 death domain involved in the recruitment of downstream kinases
M Loiarro, G Gallo, N Fanto, R De Santis… - Journal of Biological …, 2009 - ASBMB
MyD88 couples the activation of the Toll-like receptors and interleukin-1 receptor
superfamily with intracellular signaling pathways. Upon ligand binding, activated receptors …
superfamily with intracellular signaling pathways. Upon ligand binding, activated receptors …
TIR-containing adapter molecule (TICAM)-2, a bridging adapter recruiting to Toll-like receptor 4 TICAM-1 that induces interferon-β
H Oshiumi, M Sasai, K Shida, T Fujita… - Journal of Biological …, 2003 - ASBMB
Lipopolysaccharide (LPS) is an agonist for Toll-like receptor (TLR) 4 and expresses many
genes including NF-κB-and interferon regulatory factor (IRF)-3/IFN-inducible genes in …
genes including NF-κB-and interferon regulatory factor (IRF)-3/IFN-inducible genes in …
MyD88 oligomer size functions as a physical threshold to trigger IL1R Myddosome signaling
R Deliz-Aguirre, F Cao, FHU Gerpott… - Journal of Cell …, 2021 - rupress.org
A recurring feature of innate immune receptor signaling is the self-assembly of signaling
proteins into oligomeric complexes. The Myddosome is an oligomeric complex that is …
proteins into oligomeric complexes. The Myddosome is an oligomeric complex that is …
Crystal structure of Toll-like receptor adaptor MAL/TIRAP reveals the molecular basis for signal transduction and disease protection
Initiation of the innate immune response requires agonist recognition by pathogen-
recognition receptors such as the Toll-like receptors (TLRs). Toll/interleukin-1 receptor (TIR) …
recognition receptors such as the Toll-like receptors (TLRs). Toll/interleukin-1 receptor (TIR) …
A TIR domain variant of MyD88 adapter-like (Mal)/TIRAP results in loss of MyD88 binding and reduced TLR2/TLR4 signaling
K Nagpal, TS Plantinga, J Wong, BG Monks… - Journal of Biological …, 2009 - ASBMB
The adapter protein MyD88 adapter-like (Mal), encoded by TIR-domain containing adapter
protein (Tirap)(MIM 606252), is the most polymorphic of the five adapter proteins involved in …
protein (Tirap)(MIM 606252), is the most polymorphic of the five adapter proteins involved in …