Family history is the second strongest risk factor for Alzheimer disease (AD) following
advanced age. Twin and family studies indicate that genetic factors are estimated to play a …

Since the 1990s, the genetics of Alzheimer disease (AD) has been an active area of
research. The identification of deterministic mutations in the APP, PSEN1, and PSEN2 …

Three decades of genetic research in Alzheimer disease (AD) have substantially broadened
our understanding of the pathogenetic mechanisms leading to neurodegeneration and …

The rich and colorful history of gene discovery in Alzheimer's disease (AD) over the past
three decades is as complex and heterogeneous as the disease, itself. Twin and family …

Genetic factors play a major role in determining a person's risk to develop Alzheimer's
disease (AD). Rare mutations transmitted in a Mendelian fashion within affected families, for …

Alzheimer's disease (AD) is a genetically complex disorder that accounts for the majority of
dementia in the elderly population. Over 100 rare, highly penetrant mutations have been …

Alzheimer's disease (AD) is a genetically complex and heterogeneous disorder. Fully
penetrant (causal) mutations leading to predominantly early-onset familial AD have been …

Alzheimer's disease (AD) genetics may be one of the most prolifically published areas in
medicine and biology. Three early-onset AD genes with causative mutations (APP, PSEN1 …

The genetic underpinnings of Alzheimer's disease (AD) remain largely elusive despite early
successes in identifying three genes that cause early-onset familial AD (those that encode …

Alzheimer disease (AD) is the most common causes of neurodegenerative disorder in the
elderly individuals. Clinically, patients initially present with short-term memory loss …