The term Bcytokine storm^ has been adopted in the past several decades as a phrase to
describe the aberrant production of soluble mediators and the accompanying …

Infectious diseases are a leading cause of death worldwide. Sepsis is a severe clinical
syndrome related to the host response to infection. The severity of infections is due to an …

In spite of over half a century of research, sepsis still constitutes a major problem in health
care delivery. Although advances in research have significantly increased our knowledge of …

Cytokine-and anticytokine-based therapies have already entered the mainstream of medical
practice. Regulatory agencies continue to approve anticytokine therapies for patients with …

This article introduces recent advances in experimental or clinical pathophysiology and in
treatment of sepsis. Both the concept of systemic inflammatory response syndrome (SIRS) …

Sepsis is a common complication following infections, burns, trauma, and major operations
and has become the main cause of death in non-coronary intensive care units. It was the …

Sepsis remains the leading cause of death in most intensive care units. Advances in
understanding the immune response to sepsis provide the opportunity to develop more …

Sepsis, like cancer, is a disease concept that can be traced back to Greece during the time
of Hippocrates [1]. Whereas cancer described a condition of abnormal growth, sepsis was …

Sepsis is a clinical condition caused by the body's immune response to infection and
manifests as SIRS. Systemic inflammatory response syndrome is a state of systemic …

The incidence of sepsis is increasing worldwide, yet the mortality rate has barely decreased
during the past decades and remains unacceptably high at between 20%-40%. New …