Viral illnesses like SARS-CoV-2 have pathologic effects on nonrespiratory organs in the
absence of direct viral infection. We injected mice with cocktails of rodent equivalents of …

Extrapulmonary manifestations of COVID-19 are associated with a much higher mortality
rate than pulmonary manifestations. However, little is known about the pathogenesis of …

Kidneys are critical target organs of COVID-19, but susceptibility and responses to infection
remain poorly understood. Here, we combine SARS-CoV-2 variants with genome-edited …

Severe lung damage resulting from COVID-19 involves complex interactions between
diverse populations of immune and stromal cells. In this study, we used a spatial …

Background The global pandemic caused by severe acute respiratory syndrome
coronavirus 2 (SARS-CoV-2) has led to approximately 500 million cases and 6 million …

Acute kidney injury (AKI) is a common and severe complication of the coronavirus disease
2019 (COVID-19). Severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) directly …

Acute kidney injury is one of the most important complications in patients with COVID-19 and
is considered a negative prognostic factor with respect to patient survival. The occurrence of …

Background Although coronavirus disease 2019 (COVID-19) causes significan t morbidity,
mainly from pulmonary involvement, extrapulmonary symptoms are also major componen ts …

It is unclear whether severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2) can
directly infect human kidney, thus leading to acute kidney injury (AKI). Here, we perform a …

SARS-CoV-2 infections initiate cytokine storms and activate genetic programs leading to
progressive hyperinflammation in multiple organs of patients with COVID-19. While it is …