Many organs consist of tubes of epithelial cells enclosing a central lumen. How the space of
this lumen is generated is a key question in morphogenesis. Two predominant mechanisms …

The growth of a well-formed epithelial structure is governed by mechanical constraints,
cellular apico-basal polarity, and spatially controlled cell division. Here we compared the …

How do animal cells assemble into tissues and organs? A diverse array of tissue structures
and shapes can be formed by organizing groups of cells into different polarized …

Epithelial organ morphogenesis involves sequential acquisition of apicobasal polarity by
epithelial cells and development of a functional lumen. In vivo, cells perceive signals from …

The development of cell polarity in Madin-Darby canine kidney (MDCK) cells has been
analyzed under conditions in which cells are induced to form multicellular epithelial cysts in …

The asymmetric polarization of cells allows specialized functions to be performed at discrete
subcellular locales. Spatiotemporal coordination of polarization between groups of cells …

Cell polarity is fundamental for the architecture and function of epithelial tissues. Epithelial
polarization requires the intervention of several fundamental cell processes, whose …

The most fundamental type of organization of cells in metazoa is that of epithelia, which
comprise sheets of adherent cells that divide the organism into topologically and …

ABSTRACT A fundamental aspect in the morphogenesis of a polarized epithelium is the
formation of structurally and functionally distinct apical and basal-lateral domains of the …

The formation of a hollow lumen in a formerly solid mass of cells is a key developmental
process whose dysregulation leads to diseases of the kidney and other organs. Hydrostatic …