Activation of T lymphocytes by Ags or cytokines results in translocation of the transcription
factors NF-κB, AP-1, NFAT, and STAT from the cytoplasm into the nucleus. The first step in …

NF-κB transcription factors are retained in the cytoplasm in an inactive form until they are
activated and rapidly imported into the nucleus. We identified importin α3 and importin α4 as …

The transcription factor NF-κB regulates many genes involved in proinflammatory and
immune responses. The transport of NF-κB into the nucleus is essential for its biologic …

Signal-dependent nuclear translocation of transcription factor nuclear factor κB (NF-κB) is
required for the activation of downstream target genes encoding the mediators of immune …

IκBα controls the transcriptional activity of nuclear factor (NF)-κB by retaining it in the
cytoplasm; but, when expressed in the nucleus, it can also inhibit the interaction of NF-κB …

In resting cells NF-κB transcription factors are retained in the cytoplasm as latent inactive
complexes, until they are activated and rapidly transported into the nucleus. We show that all …

To control agonist-induced nuclear translocation of transcription factor κB (NF-κB) in intact
cells, cell-permeable synthetic peptides were devised. Their import into intact cells was …

Nuclear translocation of the p50/p65 heterodimer is essential for NF-κB signaling. In
unstimulated cells, p50/p65 is retained by the inhibitor IκBα in the cytoplasm that masks the …

Control over the nuclear localization of nuclear factor κB/Rel proteins is accomplished in
large part through association with members of the inhibitor of κB (IκB) protein family. For …

The inhibitor of kappa B alpha (IκBα) protein is able to shuttle between the cytoplasm and
the nucleus. We have utilized a combination of in vivo and in vitro approaches to provide …