Tricyclic antidepressants (TCAs) have potent local pain blockade properties that could be of
interest in relieving chronic pain states as neuropathic pain. The aim of this work was to …

Abstract Aim Baclofen and Lamotrigine via PLGA nanoparticles were developed for nose-to-
brain delivery for the treatment of Neuropathic pain. Methods Nanoparticles were prepared …

Duloxetine (DLX) is a selective serotonin and noradrenaline reuptake inhibitor (SNRI) used
for the treatment of pain, but it has been reported to show side effects in 10–20% of patients …

Neuroinflammation is a condition that contributes significantly to the pathogenesis and
progression of several neurodegenerative disorders. Targeting neuroinflammation is a novel …

Lamotrigine (LTG), a sodium and calcium channel blocker, has demonstrated efficacy for the
treatment of neuropathic pain in multiple, randomized, controlled trials. However, its …

Poly (d, l-lactide-co-glycolide acid)(PLGA) Nanoparticles (NPs) with sustained drug release
and enhanced circulation time presents widely explored non-invasive approach for drug …

Neuropathic pain is one of the most intense types of chronic pain; it constitutes a pervasive
complaint throughout the public health system. With few effective treatments, it remains a …

Background: Growing public awareness of chronic pain resulting from illness and injury has
prompted pharmaceutical researchers and drug corporations to create better, more targeted …

An injectable controlled release system containing local anesthetics able to provide long-
lasting analgesia in nociceptive and neuropathic pain could have a marked impact in pain …

The management of patients with neuropathic pain is challenging. Monotherapy with a
single pain relief drug may encounter different difficulties, such as short duration of efficacy …