Organic fluorine compounds have had a profound impact on the development of bioactives
for the modern pharmaceuticals market. It is estimated that up to 20% of pharmaceuticals …

Fluorine is the most electronegative element in the periodic table. When bound to carbon it
forms the strongest bonds in organic chemistry and this makes fluorine substitution attractive …

Both natural products and synthetic organofluorines play important roles in the discovery
and design of pharmaceuticals. The combination of these two classes of molecules has the …

A thorough survey of synthetic methods, chemistry, and applications of major classes of
fluorinated heterocycles Merging organic, heterocyclic, and fluoroorganic chemistry …

Fluorine, the most electronegative element plays nowadays a key role in pharmaceutical,
agrochemical and material sciences. About 20% of all pharmaceuticals and about 30% of …

It is almost one hundred years since the Belgian chemist Swarts described (in 1896) the
synthesis of methyl fluoroacetate by heating methyl iodoacetate with silver fluoride '-and …

Over the past few years, we have tackled the synthesis of interesting monofluorinated
organic molecules, such as: dihydronaphthalene derivatives, β-fluoro sulfones and related …

This review will be devoted to a description of selectively fluorinated biologically active
molecules. Selective fluorination has been an extremely effective tool for modifying …

The replacement of hydrogen atoms with fluorine substituents in organic substrates is of
great interest in synthetic chemistry because of the strong electronegativity of fluorine and …

1.1. Brief Historical Overview As expected from the fluorine position on the periodic table of
elements, it possesses some extreme properties, in particular, ultimate electronegativity and …