[HTML][HTML] Hyperactivity, perseveration and increased responding during attentional rule acquisition in the Fragile X mouse model

I Kramvis, HD Mansvelder, M Loos… - Frontiers in behavioral …, 2013 - frontiersin.org
Attentional deficits and executive function impairments are common to many
neurodevelopmental disorders of intellectual disability and autism, including Fragile X …

Cognitive dysfunction and prefrontal synaptic abnormalities in a mouse model of fragile X syndrome

DD Krueger, EK Osterweil, SP Chen… - Proceedings of the …, 2011 - National Acad Sciences
Among the hallmark phenotypes reported in individuals with fragile X syndrome (FXS) are
deficits in attentional function, inhibitory control, and cognitive flexibility, a set of cognitive …

Abnormal presynaptic short-term plasticity and information processing in a mouse model of fragile X syndrome

PY Deng, D Sojka, VA Klyachko - Journal of neuroscience, 2011 - Soc Neuroscience
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability and the
leading genetic cause of autism. It is associated with the lack of fragile X mental retardation …

Altered frontal connectivity as a mechanism for executive function deficits in fragile X syndrome

LM Schmitt, J Li, R Liu, PS Horn, JA Sweeney… - Molecular Autism, 2022 - Springer
Abstract Background Fragile X syndrome (FXS) is the leading inherited monogenic cause of
intellectual disability and autism spectrum disorder. Executive function (EF), necessary for …

Experience-dependent changes in hippocampal spatial activity and hippocampal circuit function are disrupted in a rat model of Fragile X Syndrome

A Asiminas, SA Booker, OR Dando, Z Kozic, D Arkell… - Molecular Autism, 2022 - Springer
Abstract Background Fragile X syndrome (FXS) is a common single gene cause of
intellectual disability and autism spectrum disorder. Cognitive inflexibility is one of the …

[PDF][PDF] Cell-type-specific disruption of cortico-striatal circuitry drives repetitive patterns of behavior in fragile X syndrome model mice

F Longo, S Aryal, PG Anastasiades, M Maltese… - Cell reports, 2023 - cell.com
Individuals with fragile X syndrome (FXS) are frequently diagnosed with autism spectrum
disorder (ASD), including increased risk for restricted and repetitive behaviors (RRBs) …

Sustained correction of associative learning deficits after brief, early treatment in a rat model of Fragile X Syndrome

A Asiminas, AD Jackson, SR Louros, SM Till… - Science translational …, 2019 - science.org
Fragile X Syndrome (FXS) is one of the most common monogenic forms of autism and
intellectual disability. Preclinical studies in animal models have highlighted the potential of …

[PDF][PDF] Cerebellar contribution to autism-relevant behaviors in fragile X syndrome models

JM Gibson, AH Vazquez, K Yamashiro, V Jakkamsetti… - Cell reports, 2023 - cell.com
Cerebellar dysfunction has been linked to autism spectrum disorders (ASDs). Although
cerebellar pathology has been observed in individuals with fragile X syndrome (FXS) and in …

Extinction of an instrumental response: a cognitive behavioral assay in Fmr1 knockout mice

MS Sidorov, DD Krueger, M Taylor… - Genes, Brain and …, 2014 - Wiley Online Library
Fragile X (FX) is the most common genetic cause of intellectual disability and autism.
Previous studies have shown that partial inhibition of metabotropic glutamate receptor …

Sensorimotor gating abnormalities in young males with fragile X syndrome and Fmr1-knockout mice

PW Frankland, Y Wang, B Rosner, T Shimizu… - Molecular …, 2004 - nature.com
Fragile X syndrome (FXS) is the most common single gene (FMR1) disorder affecting
cognitive and behavioral function in humans. This syndrome is characterized by a cluster of …