[HTML][HTML] Neural dynamics of autistic repetitive behaviors and Fragile X syndrome: Basal ganglia movement gating and mGluR-modulated adaptively timed learning

S Grossberg, D Kishnan - Frontiers in psychology, 2018 - frontiersin.org
This article develops the iSTART neural model that proposes how specific imbalances in
cognitive, emotional, timing, and motor processes that involve brain regions like prefrontal …

Fragile X syndrome and the amygdala

A Suvrathan, S Chattarji - Current opinion in neurobiology, 2011 - Elsevier
Fragile X syndrome (FXS) is the most commonly inherited form of mental impairment and
autism. Current understanding of the molecular and cellular mechanisms underlying FXS …

Effects of stimulus salience on touchscreen serial reversal learning in a mouse model of fragile X syndrome

PE Dickson, B Corkill, E McKimm, MM Miller… - Behavioural brain …, 2013 - Elsevier
Fragile X syndrome (FXS) is the most common inherited form of intellectual disability in
males and the most common genetic cause of autism. Although executive dysfunction is …

[HTML][HTML] Critical period plasticity is disrupted in the barrel cortex of FMR1 knockout mice

EG Harlow, SM Till, TA Russell, LS Wijetunge, P Kind… - Neuron, 2010 - cell.com
Alterations in sensory processing constitute prominent symptoms of fragile X syndrome;
however, little is known about how disrupted synaptic and circuit development in sensory …

Hippocampal dysfunction and cognitive impairment in Fragile-X Syndrome

C Bostrom, S Yau, N Majaess, M Vetrici… - Neuroscience & …, 2016 - Elsevier
Abstract Fragile-X Syndrome (FXS) is the most common form of inherited intellectual
disability and the leading genetic cause of autism spectrum disorder. FXS is caused by …

Deficits in trace fear memory and long-term potentiation in a mouse model for fragile X syndrome

MG Zhao, H Toyoda, SW Ko, HK Ding… - Journal of …, 2005 - Soc Neuroscience
Trace fear memory requires the activity of the anterior cingulate cortex (ACC) and is
sensitive to attention-distracting stimuli. Fragile X syndrome is the most common form of …

[HTML][HTML] Functional consequences of postnatal interventions in a mouse model of Fragile X syndrome

M Rais, JW Lovelace, XS Shuai, W Woodard… - Neurobiology of …, 2022 - Elsevier
Abstract Background Fragile X syndrome (FXS) is a leading genetic cause of autism and
intellectual disability with cortical hyperexcitability and sensory hypersensitivity attributed to …

[HTML][HTML] Fragile X syndrome: Lessons learned from the most translated neurodevelopmental disorder in clinical trials

PQ Duy, DB Budimirovic - Translational Neuroscience, 2017 - degruyter.com
Fragile X syndrome (FXS) is the leading genetic cause of autism spectrum disorder (ASD)
and inherited intellectual disability (ID) worldwide. Preclinical successes in understanding …

Frontostriatal deficits in fragile X syndrome: Relation to FMR1 gene expression

V Menon, J Leroux, CD White… - Proceedings of the …, 2004 - National Acad Sciences
Fragile X syndrome (fraX) is the most common known cause of inherited developmental
disability. fraX is associated with a CGG expansion in the FMR1 gene on the long arm of the …

Excitatory neuron-specific suppression of the integrated stress response contributes to autism-related phenotypes in fragile X syndrome

M Hooshmandi, V Sharma, CT Perez, R Sood… - Neuron, 2023 - cell.com
Dysregulation of protein synthesis is one of the key mechanisms underlying autism spectrum
disorder (ASD). However, the role of a major pathway controlling protein synthesis, the …