Tumor targetability and site-specific drug release of therapeutic nanoparticles are key factors
for effective cancer therapy. In this study, poly (ethylene glycol)(PEG)-conjugated hyaluronic …

Cancer is the most common cause of death worldwide; therefore, there is a need to discover
novel treatment modalities to combat it. One of the cancer treatments is nanoparticle …

In this study, intracellular pH-responsive nanoparticles (NPs) of hyaluronic acid-hydrazone
linkage-doxorubicin (HA-hyd-DOX) were designed and prepared for acid-triggered release …

Purpose The objective of the work was to evaluate the potential of hyaluronan-based
nanoparticles as tumor-targeting nano-systems for CD44-overexpressed cancer therapy …

Colon cancer is the second leading cause of cancer-related death in the United States. The
considerable mortality from colon cancer is due to metastasis to other organs, mainly the …

The in vivo stability and tumor targetability of self-assembled polymeric nanoparticles are
crucial for effective drug delivery. In this study, to develop biostable nanoparticles with high …

Hyaluronic acid (HA) has been widely investigated in cancer therapy due to its excellent
characteristics. HA, which is a linear anionic polymer, has biocompatibility, biodegradability …

In order to improve active tumor targeting, tumor cell uptake efficiency and circulation time of
doxorubicin (DOX) in vivo, we constructed a cleavable PEGylated hyaluronic acid nano-drug …

The major issues of self-assembled nanoparticles as drug carriers for cancer therapy
include biostability and tumor-targetability because the premature drug release from and …

Hyaluronic acid (HA)-based doxorubicin (DOX) nanoparticles (HA-NPs) were fabricated via
ion-pairing between positively charged DOX and negatively charged HA, which displayed …