Coronaviruses (CoVs) stand out for their large RNA genome and complex RNA-synthesizing
machinery comprising 16 nonstructural proteins (nsps). The bifunctional nsp14 contains 3 …

The emergence of SARS-CoV-2 infection has posed unprecedented threat to global public
health. The virus-encoded non-structural protein 14 (nsp14) is a bi-functional enzyme …

The SARS-CoV-2 coronavirus is the causal agent of the current global pandemic. SARS-
CoV-2 belongs to an order, Nidovirale s, with very large RNA genomes. It is proposed that …

Several life-threatening viruses have recently appeared, including the coronavirus, infecting
a variety of human and animal hosts and causing a range of diseases like human upper …

The SARS-CoV-2 coronavirus has caused a global pandemic. Despite the initial success of
vaccines at preventing infection, genomic variation has led to the proliferation of variants …

SARS‐CoV‐2 virus has triggered a global pandemic with devastating consequences. The
understanding of fundamental aspects of this virus is of extreme importance. In this work, we …

High-fidelity replication of the large RNA genome of coronaviruses (CoVs) is mediated by a
3′-to-5′ exoribonuclease (ExoN) in nonstructural protein 14 (nsp14), which excises …

Most RNA viruses lack the mechanisms to recognize and correct mutations that arise during
genome replication, resulting in quasispecies diversity that is required for pathogenesis and …

SARS-CoV-2 is a coronavirus that emerged in 2019 and rapidly spread across the world
causing a deadly pandemic with tremendous social and economic costs. Healthcare …

As coronaviruses (CoVs) replicate in the host cell cytoplasm, they rely on their own capping
machinery to ensure the efficient translation of their messenger RNAs (mRNAs), protect …