Recent advancements in next-generation sequencing technologies and accompanying
reductions in cost have led to an explosion of techniques to examine DNA accessibility and …

Transcriptional activation throughout the eukaryotic lineage has been tightly linked with
disruption of nucleosome organization at promoters, enhancers, silencers, insulators and …

Chromatin accessibility, or the physical access to chromatinized DNA, is a widely studied
characteristic of the eukaryotic genome. As active regulatory DNA elements are generally …

DNA accessibility is thought to be of major importance in regulating gene expression. We
test this hypothesis using a restriction enzyme as a probe of chromatin structure and as a …

Access to DNA is a prerequisite to the execution of essential cellular processes that include
transcription, replication, chromosomal segregation, and DNA repair. How the proteins that …

Chromatin accessibility captures in vivo protein-chromosome binding status, and is
considered an informative proxy for protein-DNA interactions. DNase I and Tn5 transposase …

Mammals contain over 200 different cell types, yet nearly all have the same genomic DNA
sequence. It is a key question in biology how the genetic instructions in DNA are selectively …

Gaining insights into the regulatory mechanisms that underlie the transcriptional variation
observed between individual cells necessitates the development of methods that measure …

Gene regulation at functional elements (eg, enhancers, promoters, insulators) is governed
by an interplay of nucleosome remodeling, histone modifications, and transcription factor …

Physical access to DNA is a highly dynamic property of chromatin that plays an essential
role in establishing and maintaining cellular identity. The organization of accessible …