Mice models of Alzheimer's disease (APP/PS1) typically experience cognitive decline with
age. G6PD overexpressing mice (G6PD-Tg) exhibit better protection from age-associated …

Gangliosides have been shown to be necessary for β-amyloid (Aβ) binding and
aggregation. GD3 synthase (GD3S) is responsible for biosynthesis of the b-and c-series …

Glucose-6-phosphate dehydrogenase (G6PD) protects the embryo from endogenous and
xenobiotic-enhanced oxidative DNA damage and embryopathies. Here we show in aged …

Compelling evidence has indicated that dysregulated glucose metabolism links Alzheimer's
disease (AD) and diabetes mellitus (DM) via glucose metabolic products. Nevertheless …

Abstract Glucose‐6‐phosphate dehydrogenase (G6PD), the rate limiting enzyme that
channels glucose catabolism from glycolysis into the pentose phosphate pathway (PPP), is …

Reduced glucose utilization is likely to precede the onset of cognitive deficits in Alzheimer's
disease (AD). Similar aberrant glucose metabolism can also be detected in the brain of …

Mice deficient in glucose-6-phosphate dehydrogenase (G6PD) cannot replenish the cellular
antioxidant glutathione, which detoxifies neurodegenerative reactive oxygen species (ROS) …

Background: Alzheimer's disease (AD) is characterized by a high etiological and clinical
heterogeneity, which has obscured the diagnostic and treatment efficacy, as well as limited …

Alzheimer disease (AD) is a major cause of age-related dementia. We do not fully
understand AD aetiology and pathogenesis, but oxidative damage is a key component. The …

Patients and individuals at risk for Alzheimer's disease show reduced glucose metabolism in
the brain. A new study takes advantage of a fly model of Alzheimer's disease to demonstrate …