Respiratory mucosal delivery of next-generation COVID-19 vaccine provides robust protection against both ancestral and variant strains of SARS-CoV-2
The emerging SARS-CoV-2 variants of concern (VOCs) threaten the effectiveness of current
COVID-19 vaccines administered intramuscularly and designed to only target the spike …
COVID-19 vaccines administered intramuscularly and designed to only target the spike …
Single-dose intranasal administration of AdCOVID elicits systemic and mucosal immunity against SARS-CoV-2 and fully protects mice from lethal challenge
RG King, A Silva-Sanchez, JN Peel, D Botta… - Vaccines, 2021 - mdpi.com
The coronavirus disease 2019 (COVID-19) pandemic has highlighted the urgent need for
effective prophylactic vaccination to prevent the spread of severe acute respiratory …
effective prophylactic vaccination to prevent the spread of severe acute respiratory …
[HTML][HTML] Protection against SARS-CoV-2 infection by a mucosal vaccine in rhesus macaques
Effective SARS-CoV-2 vaccines are urgently needed. Although most vaccine strategies have
focused on systemic immunization, here we compared the protective efficacy of 2 …
focused on systemic immunization, here we compared the protective efficacy of 2 …
[HTML][HTML] An intranasal vaccine durably protects against SARS-CoV-2 variants in mice
SARS-CoV-2 variants that attenuate antibody neutralization could jeopardize vaccine
efficacy. We recently reported the protective activity of an intranasally administered spike …
efficacy. We recently reported the protective activity of an intranasally administered spike …
[HTML][HTML] Mucosal COVID-19 vaccines: Risks, benefits and control of the pandemic
D Miteva, M Peshevska-Sekulovska… - World Journal of …, 2022 - ncbi.nlm.nih.gov
Based on mucosal immunization to promote both mucosal and systemic immune responses,
next-generation coronavirus disease 2019 (COVID-19) vaccines would be administered …
next-generation coronavirus disease 2019 (COVID-19) vaccines would be administered …
[HTML][HTML] A single-dose intranasal ChAd vaccine protects upper and lower respiratory tracts against SARS-CoV-2
The coronavirus disease 2019 pandemic has made deployment of an effective vaccine a
global health priority. We evaluated the protective activity of a chimpanzee adenovirus …
global health priority. We evaluated the protective activity of a chimpanzee adenovirus …
Single-dose intranasal vaccination elicits systemic and mucosal immunity against SARS-CoV-2
Despite remarkable progress in the development and authorization of vaccines against
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to validate …
severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2), there is a need to validate …
Prospects for mucosal vaccine: shutting the door on SARS-CoV-2
The sudden emergence of a highly transmissible and pathogenic coronavirus SARS-CoV-2
in December 2019 from China and its rapid global spread has posed an international health …
in December 2019 from China and its rapid global spread has posed an international health …
An adenovirus-vectored COVID-19 vaccine confers protection from SARS-COV-2 challenge in rhesus macaques
The rapid spread of coronavirus SARS-CoV-2 greatly threatens global public health but no
prophylactic vaccine is available. Here, we report the generation of a replication …
prophylactic vaccine is available. Here, we report the generation of a replication …
[HTML][HTML] Intranasal vaccination with a lentiviral vector protects against SARS-CoV-2 in preclinical animal models
MW Ku, M Bourgine, P Authié, J Lopez, K Nemirov… - Cell host & …, 2021 - cell.com
To develop a vaccine candidate against coronavirus disease 2019 (COVID-19), we
generated a lentiviral vector (LV) eliciting neutralizing antibodies against the Spike …
generated a lentiviral vector (LV) eliciting neutralizing antibodies against the Spike …